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Prof Juan Casas Romero
Euston Road
Tel: 02035495592
Prof Juan Casas Romero profile picture
  • Honorary Professor
  • Institute of Health Informatics
  • Faculty of Pop Health Sciences

I studied medicine at Universidad Industrial de Santander, Colombia (1999) and continue to train in cardiovascular sciences at Fundacion Cardiovascular de Colombia (1999-2002). I worked as a clinical research fellow at the centre for clinical pharmacology, UCL (2002-2005) and then joined LSHTM (2005-2015) where I obtained my PhD in Epidemiology (2009). In 2013, I was appointed as Professor of Epidemiology at LSHTM. Since 2015, I worked at the Farr Institute of Health Informatics, of which I am the Deputy Director.

I am the Director of the British Women's Heart and Health Study, Co-ordinating Editor of the Cochrane Heart Group, Co-PI of the GenPE study (www.genpe.org) and co-lead, together with Prof. Aroon Hingorani the UCLEB (UCL-LSHTM-Edinburgh-Bristol) consortium of cohorts.

Research Summary

My current research agenda is around the use of genomic-lead strategy, together with other OMICs, and electronic medical records to improve the drug discovery process and enable the precision medicine agenda. Specifics themes I am currently working are:

Theme-1: Using publicly available data on human genomics, and other OMICs, to generate knowledge-based platforms that allow to go from Genes2Medicines.

Theme-2: Using Large-scale genomics together with proteomics and metabolomics available in consented cohorts for drug-target identification, validation, repurposing, and trial optimization. For this, I use resources that I am the PI or Co-PI such as the UCLEB consortium (14 British cohorts and >40K participants), the British Women’s Heart and Health Study (multi-OMICs in 4.2K participants) and GenPE study (one the largest genetic biobanks in pre-eclampsia), and publicly available resources such as UK-Biobank.

Theme-3: Using routinely available electronic health records (hospital and primary care level) and OMICs to improve various aspects of the translational medicine pipeline, such as outcome optimisation, patient enrichment and discovery of actionable disease endo-phenotypes. 

Theme-4: The use of digital technologies (e/mHealth) to improve management in clinical care, with a focus on implementation research aspects. An example of this is the TXT2Heart trial (Co-PI): a randomised trial to improve adherence to cardiovascular medications in patients established cardiovascular disease. This trial includes Colombia, India, Ghana and Singapore.

Teaching Summary

My teaching experience expands for 16 years and include teaching at undergraduate medical students in Colombia and post-graduate student in the UK. I have been involved in a wide range of formal and informal teaching activities at UCL and LSHTM including module director of epidemiology of non-communicable diseases, and lecturer in methods in epidemioloogy, genetic epidemiology, and more recently in health informatics and drug discovery.

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