Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Prof Jim Owen
Division of Medicine, Royal Free Campus
UCL Medical School, Rowland Hill Street
Prof Jim Owen profile picture
  • Emeritus Professor of Molecular Medicine
  • Div of Medicine
  • Faculty of Medical Sciences
Research Summary

Historically, my research interests have concerned lipoprotein metabolism and cell membrane lipids, which over the years have had broad relevance to liver disease and also to cardiovascular, renal, parasitological, viral and neurological diseases. In the last 10-15 years, the focus has been on gene therapy strategies to counteract deficient or dysfunctional HDL-proteins (ApoAI, ApoE or LCAT). This included gene addition using nonviral (plasmids) and viral (recombinant adenovirus and adeno-associated virus [AAV]) vectors, with a recent emphasis on self-complementary AAV8.

In parallel, we have advanced the emerging technology of in-situ gene editing using synthetic oligonucleotides. Potential applications include introducing disease-associated mutations into cell lines or animals, functional studies of SNPs and, ultimately, clinical therapy by correcting genetic point mutations. A key target is correction of the dysfunctional e2 and e4 alleles (UK frequency 0.08 & 0.15), which are risk factors for arteriosclerosis and Alzheimer's disease. This application of oligonucleotide therapeutics is being extended to encompass exon splicing and spliceosome-mediated RNA transplicing (SMaRT) technologies to treat genetic elevation of plasma LDL.

Teaching Summary

Lectures, tutorials and workshops for the 'Cellular & Molecular Aspects of Cardiovascular Disease' module for BSc students in Molecular Medicine and in Biochemistry, Molecular Biology and Biotechnology (Bioc3011, Bioc3017 & Bioc0019). Also contributions to other courses within UCL: SSSM (The Liver - from science to clinical practice); Intercalated BSc in Clinical Sciences (UBICLSSING) (Translational Research in Cardiovascular disease); PHASE 1 YR 1 MBBS Circulation & Breathing course (Cardiovascular disease); BSc in Surgical Science (Animal models to study and treat hypercholesterolaemia and atherosclerosis); MSc in Clinical and Public Health Nutrition; and BSc in Applied Medical Sciences.  

And outside of UCL (2001 -->): Royal Holloway University of London, lectures to Biomedical Science BSc students on the 'The genetics of plasma lipoproteins in health and disease'; Universidade do Porto, Portugal - a lecture course on 'Lipoproteins and their receptors" to final year Biochemistry students; in 2014, an 8 lecture course to postgraduate students at the Universidade Federal de Pernambuco (UFPE), Recife, Brazil; and in 2018 a 2-day Scientific Writing course to students at UFPE and also at Unifor, Fortaleza, Ceara.

Academic Background
1972   Doctor of Philosophy University of London
1967   Bachelor of Science University of Nottingham
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by