I shall focus on one aspect of my research here:

My work on Intraoperative Radiotherapy (IORT) was inspired by my original laboratory work in 1994, leading to the idea that breast cancer treatment with surgery and radiotherapy needs to be focussed and targeted. 

My work on Intraoperative Radiotherapy (IORT) was inspired by my original laboratory work in 1994, leading to the idea that breast cancer treatment with surgery and radiotherapy needs to be focussed and targeted. 

Working with Professor Michael Baum and Professor Jeffrey S Tobias, in UCL, London, I developed the concept, tools (Intrabeam) and the surgical operative procedure (TARGIT IORT) to give targeted intraoperative radiotherapy to the tissues immediately around a breast cancer, after it is surgically removed (lumpectomy). I named this technique TARGIT- for TARGeted Intraoperative radioTherapy and it is commonly called Intrabeam TARGIT IORT.

The Intrabeam TARGIT IORT procedure has been now been used to treat in over 20,000 breast cancer patients worldwide. I would encourage the interested reader to visit the Intrabeam TARGIT IORT webpages giving the details of TARGIT-A trial. 

Given as a tumour bed boost, TARGIT IORT appears to achieve more than 98% durable local control in unselected cases. This has lead to the TARGIT-B trial, which will inform us whether Intrabeam TARGIT IORT given as a boost is superior to the standard radiotherapy boost.

Here are some of my talks about breast cancer research including Intrabeam TARGIT IORT.