I am one of the developers of the SPM software, which is used internationally by several thousand brain imaging researchers. Contributions to SPM relate to generative models for brain image registration and tissue segmentation (as well as informatics issues such as DICOM and other image file formats, ontology descriptions of processing procedures, user iterfaces etc). My current interests involve applying the computational anatomy framework of Grenander and others, in conjunction with pattern recognition approaches, to obtain accurate characterisations of anatomical differences among populations of subjects. This work has potential for translation into clinical practice, and relies on the establishment of large databases of scans. The emphasis is on models with predictive accuracy, rather than simple idealisations.