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Prof Jernej Ule
Department of Molecular Neuroscience, UCL Institute of Neurology
Queen Square
London
WC1N 3BG
Appointment
  • Professor of Molecular Neuroscience
  • Molecular Neuroscience
  • Institute of Neurology
  • Faculty of Brain Sciences
Biography

Jernej obtained his BSc in Molecular Biology from University of Ljubljana, Slovenia, in 1999, and PhD in Molecular Neuroscience from Rockefeller University, New York, in 2004. After two-year postdoctoral work at Rockefeller University, he started his research group at the Structural Studies department of MRC Laboratory of Molecular Biology in Cambridge in August 2006. In April 2013, his group relocated to the Department of Molecular Neuroscience at the UCL Institute of Neurology.

Research Summary

The goal of my research group is to reveal how protein-RNA and RNA-RNA interactions regulate mRNAs during brain development or disease. We employ experimental and computational techniques to determine the structure of ribonucleoprotein complexes, and to understand their role in the “life cycle” of mRNAs in the brain. We study cellular disease models, including induced pluripotent stem cells, and together with collaborators, we also study brain tissue from rodent models of neurodegenerative diseases.


To investigate protein-RNA interactions in intact cells or tissues, we developed individual-nucleotide resolution UV crosslinking and immunoprecipitation (iCLIP). iCLIP enables to map all RNA binding sites an RBP, which revealed intricate interplay between RBPs and their target mRNAs: even though RBPs control the life cycle of an mRNAs, it is the sequence, position and structure of each RNA-binding site that guides the effect of the RBPs. Thus, by mapping the binding sites of RBPs and non-coding RNAs within an mRNA, we can understand the combinatorial action of these diverse components of the RNP. We currently study how the dynamic remodelling of protein-RNA and RNA-RNA interactions within RNPs enables differentiation and plasticity of neurons, and how defects in these interactions can lead to disease.

Academic Background
2004 PhD Doctor of Philosophy – Neuroscience The Rockefeller University
1999 BSc Bachelor of Science – Neuroscience Univerza v Ljubljani
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