I am a Principle Investigator and Wellcome Trust/Royal Society Sir Henry Dale Fellow. 

The central focus of my lab lies in the development of novel and non-invasive MRI techniques to assess brain physiology with application of these methods to address key questions in neurology and neuroscience. Inspired by the recent descriptions of the glymphatic system by Dr. Nedergaard and colleagues, we have worked to develop the first non-invasive techniques to image cerebrospinal fluid-mediated brain clearance pathways, working towards improved diagnostic and treatment strategies for Alzheimer’s disease. We have since developed two novel and non-invasive MRI techniques that assess specific components of brain fluid movement implicated in the early stages of AD development: i) imaging of perivascular fluid movement [Harrison et al., 2018]; ii) imaging of aquaporin-4 mediated blood brain barrier permeability to water [Ohene et al., 2019; Ohene et al., 2020]. In addition, most recently, we have designed and validated the first non-invasive technique to assess blood-cerebrospinal fluid barrier (BCSFB) function [Evans et al., 2020]. 

I am based at the UCL Centre for Advanced Biomedical Imaging, which houses 11 different advanced imaging modalities. By working in a pre-clinical setting, this allows me to acquire precise data in highly experimentally controlled conditions with validation through comparison to invasive and ex-vivo measurements.