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Dr Ko-Fan Chen
7th Floor Queen Square House
  • Research Associate
  • Clinical & Experimental Epilepsy
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences

I studied biology and physiology for my Bachelor and Master degrees in National Cheng Kung University in Taiwan before I started my PhD with Ralf Stanewsky investigating the molecular basis of circadian light entrainment in Queen Mary University of London. For my first postdoc I joined Damian Crowther's lab in University of Cambridge, where I investigated how rhythmic light regimes alter processes underlying age related neurodegeneration. I also developed a new method for simultaneously detecting the decline of molecular and behavioural oscillations during age-dependant neurodegeneration in a fly model. Currently I am working with James Jepson in UCL Institute of Neurology to investigate Drosophila Dystonia models and continue exploring how variable light-dark cycles modify normal and disease related sleep-wake behaviour.

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Circadian rhythm is the intrinsic 24 hour oscillation of behaviours and physiology in animals and plants. Using the fruit fly Drosophila as a model organism, I have long lasting interests in understanding the neuronal-molecular mechanisms underlying how cyclic environmental factors modify sleep-wake behaviour and circadian irregularity in neuronal disorders.

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