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Mr Lucas Alvizi Cruz
Mr Lucas Alvizi Cruz profile picture
  • Research Fellow
  • Cell & Developmental Biology
  • Div of Biosciences
  • Faculty of Life Sciences
I had my bachelor degree in Biology in 2011 (University of Sao Paulo, Brazil) and PhD in Human Genetics in 2017 (University of Sao Paulo, Brazil). During my PhD and first post-doc, my main focus was on epigenomic variation in human craniofacial malformation. At UCL, under the supervision of Prof. Roberto Mayor, my research is focused on nuclear and epigenetic variation driven by mechanical changes during neural crest migration. I am an enthusiast on how environmental cues can affect development via epigenetics and also on creating new in vitro models of development.
Research Summary
My research is focused on how mechanical changes during cell migration affect the nucleus and impact their epigenome and differentiation pottential. For that, my research uses neural crest cells, which are a highly migratory cell population during development and differentiate in a range of cell types. By using in vivo and 3D in vitro models of neural crest migration, in combination with epigenomic profiling, cell imaging and cas9-based methodologies, such ideas can be addressed.
Teaching Summary
In 2011 I got my Bachelor in Biology (Institute of Biosciences, University of Sao Paulo, Brazil). During my undergrad course, I had the privilege to be part of research in Prof. Carlos Vilela's lab, in which I investigate non-criss-cross inheritance in Drosophila melanogaster, and later in Prof. Maria Rita Passos-Bueno's lab, where I investigated signalling pathways associated to cleft lip and palate, both in the department of Genetics and Evolutionary Biology (IB-USP). At Passos-Bueno's lab, I became a PhD student and focused mainly on epigenomics of human craniofacial malformation, but also had the opportunity to be trained at the Human Genome Centre (University of Sao Paulo) as a genetic counselor for families with craniofacial malformations. In 2015 I was awarded a fellowship by Sao Paulo Research Foundation and became a visiting PhD student at Philip Stanier's lab in ICH-UCL.  After receiving my PhD in 2017, I started a post-doc at the Passos-Bueno's lab and focused on gene-environment interface during craniofacial development and its consequences on the epigenome. In 2020 I became a post-doc at Prof. Roberto Mayor's lab and investigated the impact of inflammation on neural crest migration. From 2023 I started a new project in which I investigate how mechanical changes during neural crest progression affect the nucleus and impact their epigenome and differentiation pottential.
01-MAR-2020 Research fellow Cell and Developmental Biology University College London, United Kingdom
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