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Dr Louise Moyle
545
5th Floor Rockefeller Building
21 University Street
London
WC1E 6DE
Tel: 020 7697 8565
Appointment
  • Research Associate
  • Cell & Developmental Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Biography
  • Sept 2007 - July 2010: BSc Veterinary Sciences (Royal Veterinary College, University of London)
  • Oct 2010 - Nov 2014: PhD Cell and Molecular Biology, Prof. Zammit's laboratory (King's College London)
  • Nov 2014 - Feb 2015: Research Assistant, Prof. Zammit's laboratory (King's college London)
  • March 2015 - present: Postdoctoral Research Associate, Dr. Francesco Saverio Tedesco's laboratory (University College London)
Research Summary

Satellite cells and pericytes/mesoangioblasts are the two main populations of adult muscle stem cells. In healthy tissue, satellite cells predominantly repair and regenerate injuries and ensure muscle homeostasis. However, muscle pericytes have also been shown to contribute to more extensive myogenic regeneration following acute or chronic injury. 

The muscular dystrophies are a heterogenous group of inherited disorders characterised by muscle wasting and weakness. In many cases, the endogenous muscle stem cell pool becomes exhausted and cannot repair injured tissue, leading to clinical symptoms. Stem cell therapies for the muscular dystrophies have focussed on the transplantation of a healthy population of muscle stem cells into the patients muscle, in order to have longterm regeneration of the damaged tissue. However, clinical trials have shown that in humans, the engraftment efficacy of myogenic cells is low. Additionally, patients with a large amount of pathogenic tissue require multiple intramuscular injections, which further damages the muscle. Together, these issues limit the use of myogenic stem cell transplantation in the clinic.
My research in the laboratory of Dr Francesco Saverio Tedesco aims to improve the efficiency of muscle stem cell engraftment for neuromuscular disorders, including muscular dystrophy.

Academic Background
2015 PhD Doctor of Philosophy – Cell and Molecular Biology King's College London
2010 BSc Bachelor of Science – Veterinary Sciences not elsewhere classified Royal Veterinary College
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