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Dr Leo Swadling
Pears Building
Rowland Hill Street
Tel: 020 3108 2992
Dr Leo Swadling profile picture
  • Pears and Rosetrees Advanced Fellow
  • Div of Infection & Immunity
  • Faculty of Medical Sciences

I am a new group leader and Advancement Fellow in the Infection and Immunity division at UCL. I did my PhD at the University of Oxford, developing genetic and molecular technologies to optimise vaccines for viral hepatitis with Profs Ellie Barnes & Paul Klenerman. I moved to London to study liver-resident T cells with Prof Mala Maini and to characterise T cell responses to SARS-CoV-2 as part of UK-CIC (https://www.uk-cic.org/) & COVIDsortium (https://covid-consortium.com/). 




Research Themes
Research Summary

Our research aims to establish T cell correlates of protection by integrating high-resolution single-cell studies of T cell quality (function, phenotype, trafficking) and specificity (virus, protein, epitope, TCR clonality) at the extremes of controlled/uncontrolled infections, and to design vaccines to recapitulate and test correlates. 

Funded projects:

I)Defining high-resolution T cell correlates of protection in abortive versus seropositive SARS-CoV-2 Infection

Rosetrees Trust and Pears Foundation Advancement Fellowship (2022-25)

Having identified an association between RTC-specific T cells and early viral control without seroconversion or disease (Swadling et al Nature 2022), we will characterise this population using unbiased and targeted approaches to identify T cell qualities that correlate with protection. 

II)Accelerated development of an infection blocking pan-coronavirus vaccination

Therapeutic Accelerator Scheme UCL (2022-23)

To test the hypothesis that a vaccine containing early expressed and conserved CoV-2 antigens, targeted to the respiratory mucosa, will provide pan-coronavirus protection.

III)     Bioinformatic Delineation of the TCR signature of HBV control

Medical Research Foundation fellowship (2018-22): 

To identify protective TCR sequences from the site of infection for use in next generation TCR gene therapy for HBV and to probe the biological link between specificity and function.

Teaching Summary
I supervise lab rotations and placements for :

BSc -  Immunology and Infection.

iBSc - intercalated BSc in Clinical Sciences. 

MSc - Experimental and Translational Immunology

MRes - Experimental and Translational Immunology

I teach the following topics in the undergraduate and post-graduate courses above: T cell differentiation and memory development, antigen-specific T cell responses to viral infections and vaccines, vaccine development, anti-viral immunity, liver immunology and tissue residency. 

01-JUL-2022 – 30-JUN-2025 Advancement Fellow (Pears Foundation and Rosetrees trust) Infection and Immunity UCL, United Kingdom
01-AUG-2018 – 30-JUN-2022 Medical Research Foundation Fellow Infection and Immunity UCL, United Kingdom
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