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  • Emeritus Professor in Neuropsychiatry
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences
Research Themes
Research Summary
Two main interest: 1. Structural brain abnormalities in major psychosis. Current work on first episode psychosis using conventional MRI and DTI and magnetization transfer imaging (MTI). Research aims at characterising structural and cognitive abnormalities in psychosis and their natural history. Similar studies also performed in patients with bipolar disorder to determine commonality of structural changes in psychosis. A recent emphasis of my research has been the study of white matter abnormalities and structural connectivity using DTI. 2.Cognitive and psychiatric abnormalities in neurological illness. The main focus is on patients with multiple sclerosis in collaboration with neurological colleagues at the Institute of Neurology. The cognitive and psychiatric manifestations of MS have by now been well described. Current research focus on the ability of predicting the development of cognitive impairment later in the disease by susing imaging parameters obtain at disease onset. This area of research has implications as to who should be treated and when. Another related line of research is the undersanding of decision making in patients with MS and executive deficits. Other research interests are unexplained neurological symptoms (i.e. conversion, somatization disorder)
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