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Dr Massimiliano Cerletti
  • Senior Lecturer
  • Department of Ortho and MSK Science
  • Div of Surgery & Interventional Sci
  • Faculty of Medical Sciences
UCL Principal Supervisor

Dr. Massimiliano Cerletti completed his studies at the University of Milan and postdoctoral training at Harvard University, Cambridge MA, USA. Dr. Cerletti is Associate Professor in Stem Cell and Regenerative Biology at the UCL Research Department for Surgical Biotechnology and at the UCL Institute for Immunity and Transplantation, University College London, UK  

Research Summary

Dr. Cerletti’s research focuses on identifying and characterising tissue-specific stem cell populations. In particular, he is interested in a) defining regulators of muscle stem cell renewal and differentiation, b) investigating biomaterials as stem cell niche, c) topographical control of stem cell fate and function, d) dissecting determinants of ESC/iPSC mesoderm lineage differentiation, e) developing nanotechnology systems to promote tissue and organ regeneration, and f) studying mechanisms of stem cell ageing. These studies have important implications for designing new and improved strategies for clinical transplantation and for regenerative medicine. 

In 2008 Dr. Cerletti and colleagues published a pioneer article, “Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles”, Cell 2008 Jul11;134(1):37-47. These studies indicate the presence in adult skeletal muscle of prospectively isolatable muscle forming stem cells and directly demonstrate the efficacy of myogenic stem cell transplant for treating muscle degenerative disease. More recently, Dr. Cerletti and colleagues showed that metabolic factors play a critical role in directing stem cell function and that this regulation can influence the efficacy of recovery from injury and the engraftment of transplanted cells. “Short-term calorie restriction enhances skeletal muscle stem cell function”, Cell Stem Cell 2012 May 4;10(5):515-519. 

Teaching Summary

– Module Lead (Applied Medical Sciences (AMS) Year 2) – Musculoskeletal System: Ageing and Disease
– Module Lead (Module ORTHG012) – Musculoskeletal Tissue Biology II – Disease and Dysfunction 
– Lecture (Module SURGN04)  
– Lecture (Module SURGGB04) – Stem Cells and Their Applications in Surgery
– Lecture (Module ORTH3901) 
– Lecture (Module ORTHG011) – Musculoskeletal Tissue Biology I – Form and Function
– Lecture (Module SURGGN06) 
– Lecture (Module SURG2002) 

  Associate Professor UCL Centre for Nanotechnology and Regenerative Medicine Div of Surgery & Interventional Sci, Faculty of Medical Sci, United Kingdom
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