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Dr Matthew Gage
Appointment
  • BHF Senior Research Fellow
  • Metabolism & Experi Therapeutics
  • Div of Medicine
  • Faculty of Medical Sciences
Biography

BSc (Int) Hons: University of Warwick 2002 in Biological Sciences with Molecular Genetics including a year in industry.

PhD in Biochemistry 2002-2006: University of Leeds, exploring the signalling and secretory mechanisms of inflammatory cells.


Atherosclerosis is a chronic inflammatory disease of the arterial blood vessels and is the leading cause of Cardiovascular Disease.

In 2008 I joined the Division of Cardiovascular and Diabetes Research at Leeds University led by Prof. Mark Kearney working with novel models of insulin resistance and atherosclerosis to elucidate the role of the endothelium in type 2 diabetes and atherosclerosis.

In 2013 I joined Dr Inés Pineda-Torra’s group in the Division of Medicine at UCL to explore the role of Macrophage Nuclear Receptors in the development of atherosclerosis.

In 2016 I was awarded independent funding to explore how insulin affects the function of macrophages.


Recent awards:
2014 Diabetes UK Nick Hales Young Investigator Finalist - Oral presentation and poster, Liverpool, UK.
2012 British Cardiovascular Society - Young Research Workers' Prize Runner-up 2012, Manchester, UK 
2011 Diabetes UK Nick Hales Young Investigator Finalist - Oral presentation and poster, London, UK. 
2010 American Heart Association Scientific Sessions - Russell Ross Memorial Session - Oral presentation, Chicago, USA. 
2009 British Atherosclerosis Society Young Investigator Finalist - Oral presentation, Oxford, UK. 

Positions held:
2017-   UCL Metabolism and Society Domain Early careers group coordinator
2017-  BHF UCL Division of Medicine fundraising group coordinator
2015-  London Vascular Biology Forum  Early career committee member
2014-2016  UCL DoM Early careers group coordinator
2011-2013: Leeds University LIGHT Early careers group coordinator. 
2009-2013: Leeds University MCRC executive postdoctoral/graduate representative. 
2008–2013: Leeds University LIGHT sub-ethics committee member. 

Research Summary

I am currently working in Dr. Ines Pineda-Torra's group whose aims are to better understand how genes are modulated by LXR in the context of atherosclerosis to help develop improved LXR ligands for the treatment of atherosclerosis and other vascular  and inflammatory diseases.


Independently, I’m interested in how insulin affects the function of macrophages.


This is because macrophages are immune cells which play important roles in the development of diabetes and cardiovascular disease. Insulin levels in the blood are raised in people with pre-diabetes but lower in people with type 2 diabetes compared to healthy people.  

Historically, two aspects of insulin actions have been recognised: (1) it’s a growth factor in development (2) as an adult, insulin acts as a metabolic hormone on muscle, liver and fat tissue reducing blood glucose levels. Recently a third aspect of insulin’s action has emerged: the regulation of inflammation. I am investigating how changes in insulin signalling may affect the immune function of macrophages and in turn how these affected macrophages may influence type 2 diabetes and cardiovascular disease.


Appointments
01-FEB-2008 – 30-SEP-2013 Research Fellow Division of Cardiovascular & Diabetes Research University of Leeds, United Kingdom
Academic Background
2006 PhD Doctor of Philosophy – Biochemistry University of Leeds
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