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Dr Matthew Gegg
3B-101
Royal Free Medical School, Upper 3rd Floor
Rowland Hill Street
London
NW3 2PF
Tel: 020 7794 0500 35354
Appointment
- Senior Research Associate
- Clinical and Movement Neurosciences
- UCL Queen Square Institute of Neurology
- Faculty of Brain Sciences
Research Summary
Mutations in the gene encoding for glucocerebrosidase are the greatest
known genetic risk factor for developing Parkinson's disease.
Glucocerebrosidase is a lysosomal enzyme involved in sphingolipid
metabolism. Impairment of the autophagy-lysosomal pathway is implicated
in the accumulation/aggregation of alpha-synuclein and the mitochondrial
dysfunction observed in Parkinson's disease. I am investigating the
mechanisms by which glucocerebrosidase deficiency contributes to
aberrant function of the autophagy-lysosome pathway.
Academic Background
| 1999 | PhD | Doctor of Philosophy – Neurochemistry | University College London |
| 1997 | BSc Hons | Bachelor of Science (Honours) – Biochemistry | University of Bath |
