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Dr Martina Hallegger
Francis Crick Institute
1, Midland Road
London
NW11AT
Appointment
- MND Association Senior Non-Clinical Fellow
- Department of Neuromuscular Diseases
- UCL Queen Square Institute of Neurology
- Faculty of Brain Sciences
Biography
I began my scientific career during my postgraduate work at the University of Vienna, and subsequently during a Post-doctoral post in Department of Biochemistry in Cambridge with the main objective to uncover how the genetic information in our cells is amplified by combinatorial mechanisms called ‘alternative splicing’ and ‘RNA editing’. There I developed a strong background in molecular and RNA biology and global transcriptome analysis. At the University of Oxford I investigated how non-coding RNAs shape cell function, particularly in neurons affected in Parkinson’s disease. Recently I was awarded the MND Association Lady Edith Wolfson Senior Non-Clinical Fellowship.
MND Association Lady Edith Wolfson Senior Non-Clinical Fellowship 2016- 2020
Fulford Junior Research Fellowship at Somerville College, Oxford Oct 2012 - Sept 2014
Parkinson’s UK Innovation grant 2012-2014
OSCI seed funding award (Co-applicant) August 2011 – July 2012
Research Summary
I am currently an independent post-doctoral Fellow at UCL and The Francis Crick Institute in the lab of Prof Jernej Ule. I investigate how deregulated RNA metabolism contributes to the earliest events in the molecular pathogenesis of motor neuron disease. A key part of this role involves dissecting TDP-43’s function in RNA metabolism and studying this in cell lines like patient derived iPSC. By applying high-throughput methods like iCLIP (cross-linking Immuno-precipitation), RNAseq and proteomics I investigate the emerging role of RNomics in motor neuron disease biology.
