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Prof Mike Ehrenstein
Room 418
Rayne Building
5 University Street
Prof Mike Ehrenstein profile picture
  • Professor of Experimental Rheumatology
  • Inflammation
  • Div of Medicine
  • Faculty of Medical Sciences

Michael Ehrenstein is Professor of Experimental Rheumatology at University College London (UCL) and Honorary Consultant Rheumatologist at University College London Hospitals (1999-). From 1996-1999 he was an MRC Clinician Scientist at the Laboratory of Molecular Biology in Cambridge with Michael Neuberger FRS and Honorary Consultant Rheumatologist at Addenbrooke's Hospital. He obtained his PhD in 1994 at UCL on the topic of autoantibodies in systemic lupus erythematosus. He trained in medicine at the Middlesex Hospital Medical School.

Research Groups
Research Themes
Research Summary

My research group focusses on translational research in patients with autoimmune rheumatic disease. Our most recent achievement has been the BEAT-lupus trial testing the combination of the anti-BAFF therapeutic belimumab given after rituximab for patients with systemic lupus erythematous (SLE). We are now studying the immune consequences of this combination therapy to identify mechanisms of disease and biomarkers of response to therapy in SLE. Novel biologic therapies can be used as a tool to understand and manipulate the aberrant immune responses found in patients with autoimmunity. 

Other projects include:

1. The balance between pro-inflammatory (e.g. Th17) and regulatory T cell subsets in patients with rheumatoid arthritis and how we can alter this balance in favour of tolerance.

2. The effects of anti-TNF therapy on regulatory T cells in patients with rheumatoid arthritis and whether this could be used to develop clinical biomarkers.


Academic Background
1994   Doctor of Philosophy University College London
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