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Dr Malihe Eskandarpour
Appointment
  • Research Associate
  • Institute of Ophthalmology
  • Faculty of Brain Sciences
Research Summary
My research interest is to investigate how gene expression programs are controled by transcription factors, chromatin regulators (Bromodomain and Extra Terminal, BET proteins) and signalling pathways in Th17-mediated inflmmation especially in ocular inflammatory diseases. I am currently applying  molecular, cellular and animal models in a translational approach to address key questions in the role of  BET protein BRD4 in Th17 effector cells. I have already shown that targeting BET proteins ameliorate the inflammation progression in human and mouse Th17 models which was accompanied with a significant down-regulation of Th17 associated genes in response to BET inhibitors. I am currently approaching to studyy the mechanism of Th17 suppression by BET inhibitors and the effects of BET protein inhibition on Th17 master transcription factor function.
Academic Background
2008 PhD Doctor of Philosophy – Oncology Karolinska Institute
2001 MSc Master of Science – Cell and Molecular Biology University of Tehran
1997 BSc Bachelor of Science – Cell and Molecular Biology University of Tehran
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