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Dr Michela Esposito
Dr Michela Esposito profile picture
  • Research Fellow
  • Dept of Med Phys & Biomedical Eng
  • Faculty of Engineering Science

I am an early career researcher with extensive experience in developing instrumentation for medical and biological applications. I have worked on many projects in large multi-disciplinary and translational collaborations, benefiting from the broad spectrum of expertise as well as learning to collaborate across different disciplines to achieve a common objective. My research has been at the interface between academia and industry, and I have been able to engage directly in the full instrument development cycle: from a research idea to proof of concept, and finally to product development.


During my PhD at the University of Surrey, I contributed to the development of large-area CMOS sensors, at a time when they were just started being translated from the consumer market to scientific applications. I built my postdoctoral experience in developing imaging instrumentation to support image-guided proton beam therapy for which I am one of the inventors on two awarded patents and the lead inventor on a third one.


Looking for a new challenge, in 2020 I changed my research field and moved to UCL where, as a member of the Advanced X-ray Imaging (AXIM) group, I focused on the development on novel phase-based imaging instrumentation for soft tissue imaging.

Research Summary

My research focuses on the development of novel instrumentation and methods for multi-scale three-dimensional imaging of soft tissue specimens at microscopic scale lengths.


I have led the development of a laboratory-based x-ray microscope (Esposito et al., Appl. Phys. Lett. 120(33), 2022; Esposito et al., Proc. SPIE 12031, Medical Imaging 2022) offering tomographic imaging with resolution and contrast comparable to state-of-the-art synchrotron facilities, i.e. down to the cellular level. This imaging platform is designed for high flexibility to match different imaging needs as well as different imaging modalities; importantly, its phase sensitivity gives it exquisite soft-tissue contrast, unavailable to conventional x-ray approaches. Multi-modal contrast achievable with the microscope (micro-radian scattering is available as well as phase and conventional attenuation) allows for the detection of low contrast details in soft tissue (e.g., chondrocytes in cartilage), visualisation of details below the system resolution (e.g., bundles of collagen fibrils and axons in nerve fascicles) and material identification.

JUL-2018 – MAR-2020 Lecturer (fixed term) School of Computer Science & School of Mathematics and Physi University of Lincoln, United Kingdom
FEB-2013 – DEC-2017 Research fellow School of Computer Science & School of Mathematics and Physi University of Lincoln, United Kingdom
SEP-2010 – JAN-2013 Research Assistant Centre for Vision, Speech and Signal Processing University of Surrey, United Kingdom
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