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Mr Manish Chand
3rd Floor
Wellcome Trust EPSRC Centre, Charles Bell House
43 Foley Street
London
W1W 7JN
Appointment
  • Clinical Senior Lecturer
  • Department of Targeted Intervention
  • Div of Surgery & Interventional Sci
  • Faculty of Medical Sciences
Role
UCL Subsidiary Supervisor
Biography

Mr Chand is currently a Consultant Colorectal Surgeon and Associate Professor at University College London. He is also Director of the MS in Advanced Minimally-Invasive Surgery at UCL.

After completing a 1st Class BSc in Neurosciences from Kings College London, Mr Chand graduated from Royal Free Hospital London with MBBS (Hons) and subsequently went on to teach Anatomy and Physiology at Oxford University. He remained an Honorary Neurosciences tutor at Balliol College, Oxford for a further 5 years during which time he completed his Basic Surgical Training through Kings College Hospital London. Whilst completing Higher Surgical Training through the Wessex training scheme including the prestigious Basingstoke Hospital under Bill Heald and Brendan Moran, he gained a PhD from The Royal Marsden Hospital and Imperial College working with the MERCURY Study Group under the supervision of Professor Gina Brown.

Mr Chand has presented several lectures across the globe, has over 100 peer-reviewed publications and book chapters and is involved at editorial level on surgical journals. He is a Key Opinion Leader and recognised expert in laparoscopic rectal surgery and imaging of rectal cancer working closely with innovative digital surgery research including the AIS Channel and Touch Surgery. Currently, Mr Chand leads colorectal cancer research at University College London specifically fluorescence guided surgery, advanced imaging modalities and augmented reality. This includes supervising a number of postgraduate students. The Masters programme of which he is Director is considered the most innovative and technologically advanced surgery programme of its type with a leading international faculty. Mr Chand also holds an MBA and a keen interest in the management of complex institutions.

Research Themes
Research Summary

Surgical Technology and Artificial Intelligence

Increasingly, surgery is being performed by means of minimally-invasive approaches using high definition cameras. These laparoscopic or robotic procedures contain a wealth of video data which can be used to predict outcomes through the use of intelligent algorithms. Our lab has expertise in harnessing artificial intelligence techniques and using them with surgical video data to recognize optimal practice and help predict error. We are actively studying these techniques across a number of different surgical procedures. 

Virtual Reality and Augmented Reality in Surgery

The use of complex imaging technology can greatly improve management in surgery. This encompasses cancer and non-cancer conditions. Specifically, I have a research interest in complex imaging modalities that can better guide surgery to improve outcomes and how this can be incorporated into virtual and augmented reality models to improve training and execution of surgery. This includes stereotactic surgery to improve surgical precision in colorectal cancer and inflammatory bowel disease. Using these technologies, we will be able to develop more complex platforms to rehearse surgery and ultimately become more accurate in our ability to remove disease. Much of this work is conducted in conjunction with my cross-disciplinary colleagues at UCL including the School of Engineering and Robotics/Haptics. 

Fluorescence-guided Surgery

There is increasing use of fluorophores to improve surgical and oncological outcomes. Through a competitive funding application, I have been able to acquire a specific laparoscopic camera system which is able to excite Indocyanine Green (ICG) and demonstrate near-infrared fluorescence in the vascular and lymphatic system. I am currently involved in Phase I, II and Phase III trials looking at how the use of fluorophores can improve patient outcomes in laparoscopic surgery. The use of fluorophores will greatly improve our surgical precision in the future in conjunction with complex imaging modalities which can be integrated into laparoscopic and robotic platforms. To this end I am involved in the research and design of upcoming platforms with commercial partners.

Imaging Biomarkers

The management of rectal cancer has been greatly enhanced by a better understanding of disease progression and spread. Whilst precise surgical technique has led to historically low rates of local recurrence, the challenge of distant disease recurrence and ultimately, overall survival still remain. By relating predictive and prognostic tumoural characteristics that are accurately identifiable on non-interventional modalities such as MRI to tumorigenic pathways, novel therapeutic pathways may be exploited for optimal patient management. Working with the Royal Marsden Hospital, Imperial College London and MERCURY Research Group led by Professor Gina Brown and Professor Paris Tekkis, I have been able to relate a specific adverse phenotypical feature of rectal cancer, namely extramural venous invasion (EMVI) to specific patterns of disease recurrence and specific behavior to oncological therapy. 



Teaching Summary

Mr Chand is the Director of the Advanced Minimally-Invasive Surgery MSc at University College London. This is considered one of the most technologically advanced degree programmes covering a number of the most cutting edge techniques in surgery. There is a particular focus on hands-on skills using the Da Vinci Xi and high definition laparoscopic trainers. The faculty includes some of the world’s best known trainers in MIS and we are fortunate to have a truly international cohort of students each year. 


Mr Chand is also faculty for the Institute of Cancer Research MSc in Oncology. In addition, he teaches on a number of national and international courses.

Appointments
01-OCT-2018 Associate Professor of Surgery Surgery and Interventional Sciences University College London, United Kingdom
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