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Dr Mark Little
1/670
UCL Centre for Nephrology Royal Free
Rowland Hill St
London
NW3 2QG
Tel: 34903
Appointment
  • Honorary Senior Lecturer
  • Div of Medicine
  • Faculty of Medical Sciences
Research Summary

My work aims to understand the immunopathogenic mechanisms underlying the development of glomerulonephritis, with a specific focus on ANCA-associated vasculitis. This is the commonest cause of rapidly progressive glomerulonephritis and is associated with autoimmunity directed against components of the neutrophil cytoplasm. The driving force behind this aim is the clinical need for biomarkers that accurately identify active vasculitis, and which predict those in whom immunosuppressive therapy can be safely withdrawn. The research strands that will help to address this aim include:

1.       In vitro characterisation of the functional effects of ANCA on neutrophils, with focus on use of systems biology approaches to define the intracellular perturbations induced by this autoantibody. These approaches include metabolomic and expression arrays.

2.       Development of improved in vivo systems to accurately model the pathological processes, thereby allowing generation and testing of novel biomarkers and therapies.

3.       Development of national and international clinical data sets linked to bio-repositories that will facilitate research on well phenotyped patient samples collected over time, and at different stages of the disease. Central to this effort is the UKVAS vasculitis registry.

4.       Improvement in imaging technologies to allow accurate non-invasive characterisation of the anatomical defects and degree of inflammation in upper airway granulomatosis with polyangiitis.

5.       Collaboration with the EUVAS international vasculitis clinical investigation group and the European Vasculitis Genetics Consortium with respect to clinical trials and large scale genetics studies.

Appointments
01-AUG-2009 Senior Lecturer UCL Centre for Nephrology Royal Free UCL, United Kingdom
01-OCT-2006 – 31-JUL-2009 Senior Lecturer Renal Immunobiology University of Birmingham, United Kingdom
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