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Mr MINWEI LIU
Room 9/230
UCL Division of Surgery and Interventional Science
9th Floor, Royal Free Hospital, Pond Street
London
NW3 2QG
Mr MINWEI LIU profile picture
Appointment
  • Student
  • Div of Surgery & Interventional Sci
  • Faculty of Medical Sciences
Biography
Graduated from Guangdong Technion - Israel Institute of Technology (GTIIT) and obtained the Bachelor’s Degree (Bachelor of Engineering - BEng) in Chemical Engineering from GTIIT and the Bachelor’s Degree (Bachelor of Science - BSc) in Chemical Engineering from Technion - Israel Institute of Technology in August 2021. Worked as a Peer Tutor for the course Fundamentals of Chemistry (December 2018 - January 2019) and Ordinary Differential Equations (March 2019 - June 2019). Worked as a Teaching Assistant for the course Intro.to Probability and Statistics (October 2019 - February 2020) and a Research Assistant in Environmental Engineering (for doing UG Senior Thesis, September 2020 - July 2021).


Joined in University College London (UCL) as an PhD student in Surgery and Interventional Science (Faculty of Medical Sciences) in November 2021.

Research group: Precision Nano Systems and Advanced Therapy (Principal Supervisor: Assoc. Prof. Hirak Patra;  Subsidiary Supervisor: Prof. Nikolitsa Nomikou;)

Research Field: Nanomedicine. 

The research topic is Cascade Programmed Drug Release For Multidrug Resistance Cancer. For the details about the research, the β-Lapachone (Lapa), Larotrectinib and boronated doxorubicin (BDOX) will be loaded into the liposomal/micellar system in order to form the Cascade programmed Nanoparticle (CpN). Subsequently, CpN will be delivered to the 3-dimensional (3D) multicellular tumour spheroids (MCSs) of multidrug resistance (MDR) cancer cells (such as Head and Neck Squamous Cell Carcinoma (HNSCC)) after the surface functionalisation. In addition, Reactive Oxygen Species (ROS) – responsive system will be applied for triggering the BDOX release. The cascade drug release and the therapeutic efficacy will be evaluated in the 3D/MCSs in vitro model. Consequently, the outcomes of the research will provide strong evidence and valuable data on whether and how the CpN strategy could be useful to combat the MDR cancers and how could that be translated into clinics.


Research Summary
Joined in University College London (UCL) as an PhD student in Surgery and Interventional Science (Faculty of Medical Sciences) in November 2021. 


Research group: Precision Nano Systems and Advanced Therapy (Principal Supervisor: Assoc. Prof. Hirak Patra;  Subsidiary Supervisor: Prof. Nikolitsa Nomikou;). 

Research Field: Nanomedicine. 

The research topic is Cascade Programmed Drug Release For Multidrug Resistance Cancer. For the details about the research, the β-Lapachone (Lapa), Larotrectinib and boronated doxorubicin (BDOX) will be loaded into the liposomal/micellar system in order to form the Cascade programmed Nanoparticle (CpN). Subsequently, CpN will be delivered to the 3-dimensional (3D) multicellular tumour spheroids (MCSs) of multidrug resistance (MDR) cancer cells (such as Head and Neck Squamous Cell Carcinoma (HNSCC)) after the surface functionalisation. In addition, Reactive Oxygen Species (ROS) – responsive system will be applied for triggering the BDOX release. The cascade drug release and the therapeutic efficacy will be evaluated in the 3D/MCSs in vitro model. Consequently, the outcomes of the research will provide strong evidence and valuable data on whether and how the CpN strategy could be useful to combat the MDR cancers and how could that be translated into clinics.


Appointments
01-NOV-2021 – 31-OCT-2025 PhD researcher Division of Surgery and Interventional Science University College London, United Kingdom
SEP-2020 – JUL-2021 Research Assistant (for doing UG senior thesis)   Guangdong Technion - Israel Institute of Technology, China
OCT-2019 – FEB-2020 Teaching Assistant (Intro.to Probability and Statistics)   Guangdong Technion - Israel Institute of Technology, China
MAR-2019 – JUN-2019 Peer Tutor (Ordinary Differential Equations)   Guangdong Technion - Israel Institute of Technology, China
DEC-2018 – JAN-2019 Peer Tutor (Fundamentals of Chemistry)   Guangdong Technion - Israel Institute of Technology, China
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