Email: portico-services@ucl.ac.uk
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- Student
- Div of Surgery & Interventional Sci
- Faculty of Medical Sciences
Joined in University College London (UCL) as an PhD student in Surgery and Interventional Science (Faculty of Medical Sciences) in November 2021.
Research group: Precision Nano Systems and Advanced Therapy (Principal Supervisor: Assoc. Prof. Hirak Patra; Subsidiary Supervisor: Prof. Nikolitsa Nomikou;)
Research Field: Nanomedicine.
The research topic is Cascade Programmed Drug Release For Multidrug Resistance Cancer. For the details about the research, the β-Lapachone (Lapa), Larotrectinib and boronated doxorubicin (BDOX) will be loaded into the liposomal/micellar system in order to form the Cascade programmed Nanoparticle (CpN). Subsequently, CpN will be delivered to the 3-dimensional (3D) multicellular tumour spheroids (MCSs) of multidrug resistance (MDR) cancer cells (such as Head and Neck Squamous Cell Carcinoma (HNSCC)) after the surface functionalisation. In addition, Reactive Oxygen Species (ROS) – responsive system will be applied for triggering the BDOX release. The cascade drug release and the therapeutic efficacy will be evaluated in the 3D/MCSs in vitro model. Consequently, the outcomes of the research will provide strong evidence and valuable data on whether and how the CpN strategy could be useful to combat the MDR cancers and how could that be translated into clinics.
Research group: Precision Nano Systems and Advanced Therapy (Principal Supervisor: Assoc. Prof. Hirak Patra; Subsidiary Supervisor: Prof. Nikolitsa Nomikou;).
Research Field: Nanomedicine.
The research topic is Cascade Programmed Drug Release For Multidrug Resistance Cancer. For the details about the research, the β-Lapachone (Lapa), Larotrectinib and boronated doxorubicin (BDOX) will be loaded into the liposomal/micellar system in order to form the Cascade programmed Nanoparticle (CpN). Subsequently, CpN will be delivered to the 3-dimensional (3D) multicellular tumour spheroids (MCSs) of multidrug resistance (MDR) cancer cells (such as Head and Neck Squamous Cell Carcinoma (HNSCC)) after the surface functionalisation. In addition, Reactive Oxygen Species (ROS) – responsive system will be applied for triggering the BDOX release. The cascade drug release and the therapeutic efficacy will be evaluated in the 3D/MCSs in vitro model. Consequently, the outcomes of the research will provide strong evidence and valuable data on whether and how the CpN strategy could be useful to combat the MDR cancers and how could that be translated into clinics.
01-NOV-2021 – 31-OCT-2025 | PhD researcher | Division of Surgery and Interventional Science | University College London, United Kingdom |
SEP-2020 – JUL-2021 | Research Assistant (for doing UG senior thesis) | Guangdong Technion - Israel Institute of Technology, China | |
OCT-2019 – FEB-2020 | Teaching Assistant (Intro.to Probability and Statistics) | Guangdong Technion - Israel Institute of Technology, China | |
MAR-2019 – JUN-2019 | Peer Tutor (Ordinary Differential Equations) | Guangdong Technion - Israel Institute of Technology, China | |
DEC-2018 – JAN-2019 | Peer Tutor (Fundamentals of Chemistry) | Guangdong Technion - Israel Institute of Technology, China |