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Prof Martin Brown
National Hospital for Neurology & Neurosurgery, UCL
Queen Square
  • Principal Clinical Research Associate
  • Brain Repair & Rehabilitation
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences
Research Themes
Research Summary
SYMPTOMATIC CAROTID ARTERY STENOSIS Carotid artery stenosis is an important cause of stroke. Professor Martin Brown is the Chief Investigator responsible for organising, collecting data and analysing results from the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS) and the International Carotid Stenting Study (ICSS). These are multicentre randomised controlled trials comparing carotid endarterectomy with endovascular treatment (angioplasty with or without stenting) for recently symptomatic carotid stenosis. Early results from CAVATAS showed that endovascular treatment had similar major risks and effectiveness at prevention of stroke during 3 years compared with surgery with the advantage of avoiding minor complications such as cranial neuropathy. This research programme on carotid artery surgery and stenting has had substantial influence on practice and service delivery and the prevention of stroke from carotid artery atherosclerosis The preliminary results of CAVATAS have informed the National Clinical Guidelines for Stroke and the NICE recommendations on Carotid Stenting. ICSS is a follow on study from CAVATAS, designed to compare primary stenting (a newer technique) with carotid surgery. ICSS has promoted the prudent development of optimal carotid stenting in the UK and incorporates arrangements for training radiologists in carotid stenting. ICSS will complete recruitment of over 1,700 patients from more than 50 neuroscience centres in Europe, Canada, Australia and New Zealand in 2008. Locally, we are also undertaking a study to identify patients at increased risk of complications from carotid stenting. This uses a special magnetic coil to image the deposits of atherosclerosis causing the carotid narrowing, and ultrasound equipment to measure blood flow and detect small blood clots and other particles which break off from the patch of atherosclerosis. FACILITATION OF MULTICENTRE CLINICAL TRIALS
Academic Background
1994 FRCP Fellow of the Royal College of Physicians – Clinical Medicine Royal College of Physicians
1984 MA Master of Arts University of Cambridge
1984 MD Doctor of Medicine – Medicine University of Cambridge
1978 MRCP Member of the Royal College of Physicians – Clinical Medicine Royal College of Physicians
1975 MB BCh Bachelor of Medicine, Bachelor of Surgery – Medicine/Surgery University of Cambridge
1972 BA Hons Bachelor of Arts (Honours) University of Cambridge
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