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Prof Martina Micheletti
Bernard Katz Building
Prof Martina Micheletti profile picture
  • Professor of Bioprocess Fluid Dynamics
  • Dept of Biochemical Engineering
  • Faculty of Engineering Science

Martina is Professor of Bioprocess Fluid Dynamics at UCL Department of Biochemical Engineering and co-Director of the EPSRC/DHSC Future Research Vaccine Manufacturing Hub (Vax-Hub). She is Associate Member of the Institution of Chemical Engineers (AMIChemE) and a Fellow of the Higher Education Academy (FHEA).


Previous and current roles include:

- European Federation of Biotechnology, M3C working party (2012 – 2014)

- ECI Single-Use Technologies conference (founding member, 2015 – 2017)

- ECI Single-Use Technologies conference (Chair, 2017 – 2021)

- IChemE Fluid Mixing Special Interest Group Committee (Member, 2018 - )

- European Federation of Chemical Engineering – Working party on mixing (Member, 2019 - )


Martina joined UCL in 2004 as a postdoctoral research associate working on an interdisciplinary Programme on Biocatalysis integrated with Chemistry and Engineering (BiCE) at UCL Department of Biochemical Engineering. She was then appointed a Lecturer in the same department in 2007. Academic qualifications include a Laurea (MEng) in Chemical Engineering (University of Pisa) and a PhD in Mechanical Engineering (2004) from King’s College London.

Research Themes
Research Summary

Martina leads research in mixing and fluid dynamics applied to bioprocesses and has applied her novel techniques and rigorous approach to obtain fundamental understanding of single-use bioreactor technologies and in increasingly important sectors like cell and gene therapy, continuous production of monoclonal antibodies and vaccine manufacture. She is currently co-Director of the Future Research Vaccine Manufacturing Hub (Vax-Hub) with Professor Dame Sarah Gilbert (University of Oxford).


Her main line of research focuses on the fundamental engineering characterisation of upstream technologies for improved scale-up. She has applied her expertise in the use of advanced optical techniques for the measurement and quantification of flow characteristics and mixing dynamics to different systems: bioreactors, primary recovery and scale-down. She has established an entirely new area within the department focused on the characterisation, design and use of single-use bioprocess technologies, which have led to key outcomes in prestigious journals. Martina has worked on automated microscale bioprocessing techniques and has recently applied these to new areas, namely process development of novel glycoconjugate vaccine technologies and as novel high throughput methods for mammalian cell culture perfusion processes.


Current grants include the EPSRC DHSC Future Vaccine Manufacturing Hub (Director, EP/X038181/1), which was recently awarded a 1 year Continuation grant and additional funding EP/X03867X/1), and several industrial awards and EngD students, co-funded by the EPSRC Doctoral training Centre in Bioprocess Engineering (EP/L01520X/1 and EP/S021868/1) and companies like Pfizer, Pall Biotech, AstraZeneca. MSD among others.


Martina has had a long-standing involvement with Engineering Conferences International (ECI) having chaired sessions and presented at their Integrated Continuous Biomanufacturing, Vaccine Technologies and Single-Use Technologies conferences. She was Co-Chair of the Single-Use Technologies conference in 2017 and 2021 with Magali Barbaroux (Sartorius) and Weibing Ding (Amgen).

Teaching Summary

Martina's teaching activities contribute to the various undergraduate and postgraduate IChemE accredited degree programmes operated by the department. She leads on fluid mechanics teaching across the department, alongside teaching of single-use technologies across all years of the various degree course programmes operated by the Department. She organizes a scenario focusing on mixing fundamentals underpinning cellular agriculture methods (Year 1, in collaboration with Dr Petra Hanga) and leads on laboratory skills module for the MSc in Biochemical Engineering programme.


At Masters level she contributes to the department’s MBIâ Training Programme for industry to modules on Mammalian Cell Processes, Vaccine Technologies and Smart Digitalisation Decisions in Bioprocessing. She leads on the development of a new online and open access course offering in tools and technologies underpinning vaccine manufacturing, stemmed from the work of several researchers within Vax-Hub. At doctoral level she is first supervisor of several EngD students within the Centre for Doctoral Training in Bioprocess Engineering.


Key themes in my teaching career at UCL have focused on developing new ideas and innovative methodologies (flipped lecture approach and problem-based learning) and introducing them into the teaching portfolio, especially with regards to the relationship between teaching and research, feedback and assessment. These now encourage a deep approach to learning through the use of team-based case studies and problem-solving exercises, purposely designed to facilitate the application of transport process analysis to practical bioprocess-oriented problems. I have also implemented new formative assessment methods and the use of an e-learning environment for feedback and forum discussions within this course. My achievements were recognized by a Royal Academy of Engineering ExxonMobil Excellence in Teaching award in 2011and by several students and Faculty-led nominations for teaching awards.


17-SEP-2007 Lecturer Biochemical Engineering UCL, United Kingdom
01-JUN-2004 – 16-SEP-2007 Postdoctoral Research Associate Biochemical Engineering UCL, United Kingdom
Academic Background
2012   ATQ03 - Recognised by the HEA as a Fellow University College London
2004   Doctor of Philosophy King's College London
2000   Laurea Universita degli Studi di Pisa
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