Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Michael Bowl
Dr Michael Bowl profile picture
  • Principal Research Fellow
  • The Ear Institute
  • Faculty of Brain Sciences

I am a Principal Research Fellow at the UCL Ear Institute. I have a BSc (Hons) Medical Biochemistry and MPhil (Res) Molecular and Cellular Immunology and Oncology from the University of Birmingham, and completed my DPhil studies within the Nuffield Department of Clinical Medicine at the University of Oxford. In 2010, I joined the Mammalian Genetics Unit at the MRC Harwell Institute, initially as a Senior Investigator Scientist within the Genetics and Pathobiology of Deafness Programme and more recently as the Programme Lead for the Sensorineural Hearing Loss research. In this role, I have been heavily involved in large-scale phenotype- and gene-driven programmes aimed at uncovering gene function in the mouse. Using these approaches my team and I have successfully identified and characterized novel genes that are essential for mammalian auditory function. In July 2020, I joined the UCL Ear Institute as a Principal Research Fellow, and will begin a 3-year honorary MRC Senior Non-Clinical Fellowship in April 2022.

Research Summary

Currently, our limited knowledge of the genetic landscape of deafness is an impediment to: providing a genetic diagnosis to patients; the design of mechanistic studies; and, the development of therapeutic interventions. Indeed, we are still naïve to the complete genetic program that underlies cochlear sensory hair cell identity, function and maintenance. The research aim of my lab is to increase understanding of these genetic programs, with a particular focus on age-related hearing loss (ARHL). ARHL is a complex disease that is influenced by environmental factors and genetic susceptibility. Moreover, a recent Lancet Commission on Dementia (Livingston et al, 2017) identifies midlife peripheral hearing loss as the highest individual risk factor for dementia, and this is pertinent as ARHL is the most prevalent sensory deficit within the population (affects >30% of individuals older than 55-years). However, currently little is known about the genes underlying ARHL. Using the mouse as a model, my team and I utilise both forward and reverse genetic approaches to elaborate upon genes that are essential for mammalian hearing. In addition, we work closely with collaborators who are undertaking GWAS and exome sequencing screens in ARHL families/cohorts and generate CRISPR/Cas9-mediated mouse models for the highest-ranked genes/alleles arising from these studies. These models allow us to: validate the involvement of genes in ARHL causation; identify critical molecular and cellular processes occurring in the aging mammalian ear; determine the pathobiology associated with disease progression, something that is not possible in humans; and, assess for mechanistic links underlying cognitive decline associated with peripheral hearing loss.

Together this increased knowledge will lay the foundations necessary for developing therapeutic strategies to ameliorate progressive hearing loss, and potentially reduce dementia incidence.
2020 Principal Research Fellow Ear Institute UCL, United Kingdom
2018 – 2022 Programme Lead - Sensorineural Hearing Loss Mammalian Genetics Unit MRC Harwell Institute, United Kingdom
2010 – 2018 Senior Investigator Scientist Mammalian Genetics Unit MRC Harwell Institute, United Kingdom
2006 – 2008 Junior Research Fellow Linacre College University of Oxford, United Kingdom
2003 – 2010 Post-doctoral Scientist Nuffield Department of Clinical Medicine University of Oxford, United Kingdom
Academic Background
  BSc Hons Medical Biochemistry University of Birmingham
  MRes Molecular and cellular immunology and oncology University of Birmingham
  DPhil Molecular genetics of hypoparathyroid disorders University of Oxford
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by