The overarching theme of the lab is mitochondrial biology, physiology and pathophysiology. A central theme has been the relationship of mitochondria with cellular calcium signalling, but much current work explores aspects of mitochodrial quality control pathways, especially in relation to neurodegenerative disease. Mitochondrial integrity and energy homeostasis are key to cell health; multiple aspects of mitochondrial function have a major impact on cell health, function and fate – energetic competence, trafficking and dynamics, turnover, processing of intermediary metabolites and cell death pathways. This is all so fundamental, that it is not surprising that mitochondrial dysfunction is implicated in the pathophysiology of a wide range of major human diseases. It is therefore critical to understand the mechanisms by which the health of the mitochondrial population is maintained, how mitochondria contribute to cell and organ physiology and pathophysiology and to understand pathways that regulate mitochondrial function and bioenergetic homeostasis, how these change in specific diseases, and then to ask whether these represent potential novel therapeutic targets for otherwise intractable disease. Current work in the lab addresses these questions in a range of  models in which the common central theme is the understanding of disease mechanism and identification of novel potential therapeutic strategies