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Dr Matthew Reeves
Institute of Immunity & Transplantation
Royal Free Campus
Hampstead
London
NW3 2PF
Tel: 0207794 0500 ext 33109
Appointment
  • Lecturer
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
 
 
Biography


Research Summary
Human cytomegalovirus (HCMV) is an opportunistic pathogen that is a significant cause of morbidity and mortality in immune-compromised individuals. Like all herpesviruses, HCMV establishes a lifelong latent infection in the host and a major site of latency is the cells of the myeloid lineage; latency being established in a sub-population of CD34+ progenitor cells in the bone marrow. Only upon normal differentiation of these cells to macrophages or dendritic cells (DCs) is reactivation detected. Consequently, it is hypothesised that changes in the cellular environment concomitant with differentiation also promote reactivation.

It is becoming increasingly clear that throughout latency (from establishment to maintenance and, ultimately, reactivation) there is a complex interplay between the virus and the cell. Our own studies are mainly focussed on the events that occur at the point of entry into the cellular site of latency and the mechanisms that trigger reactivation. In both instances, we are interested in the role of cellular signalling and, furthermore, the viral mechanisms that contribute to the successful utilisation of these cellular pathways.

Through these studies we hope to further our understanding of the complex interaction between the host and pathogen and,specifically, the intimate relationship persistent viruses have with their host. It is envisaged these studies will also provide the basis for the development of novel therapeutic strategies.

 

Academic Background
2005 PhD Doctor of Philosophy University of Cambridge
2000 BSc Hons Bachelor of Science University of Manchester
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