Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Matthew Reeves
Institute of Immunity & Transplantation
Royal Free Campus
Dr Matthew Reeves profile picture
  • Associate Professor
  • Div of Infection & Immunity
  • Faculty of Medical Sciences

PhD: The regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling. University of Cambridge (Profs. Sissons & Sinclair)

Post Doctoral Associate: the anti-apoptotic function of virally expressed untranslated RNA. University of Cambridge (Prof. Sinclair)

Presidential Fellowship: Cellular signalling in HCMV latency and reactivation. Novartis, Massachussets, USA (Prof. Compton)

MRC CDA Fellowship: Impact of cellular signalling and viral gene expression on reactivation of HCMV from latency (University of Cambridge/ UCL)

Associate Professor: Institute of Immunity & Transplantation, UCL.

Research Summary
Human Cytomegalovirus (HCMV) remains a major clinical complication in a number of settings including immune-suppressed transplant patients and following congenital infection. The ability of HCMV, like all herpes viruses, to establish a lifelong latent infection of the host results in the threat posed by HCMV as twofold: Transplant patients are at risk following primary infection or following the reactivation of the latent virus that resides in the recipient.

​Our group is part of the CMV research group (with Prof Griffiths) and is focused on dissecting the molecular basis of HCMV latency and reactivation, the role of host cell functions during lytic infection, and the identification of determinants of viral pathogenesis in vivo. Questions we are addressing include:

1) The contribution of both viral and cellular functions to viral latency with particular emphasis on how cell signalling pathways are important during both the establishment and reactivation phases of the latent infection.

​2) The natural history of HCMV in solid organ transplant patients. Here the focus is to understand the role of viral genetics and host immunity in the onset of viraemia in these patients with a view to a clearer understanding of why certain individuals are at increased risk of HCMV pathogenesis post transplant.

​3) The mechanistic basis of protection afforded by the HCMV gB vaccine. A number of HCMV vaccines have been developed but none are licensed to date. The gB vaccine has shown partial protection in 3 phase II trials and now the challenge is to understand why it was protective and how we can make it better. By extension, we will use this to learn about the role of gB in the entry process of HCMV.

​4) The development of novel strategies to target HCMV therapeutically. A major aspect of this approach is to use these as tool compounds to probe the biology of HCMV and gain new insight into the biology of the host:pathogen interaction. One aspect is to utilise an anti-viral approach that empowers a more effective response by the humoral immune system.

5) We apply our knowledge and understanding to the study of other pathogens where appropriate. Currently, we are interested in BK polyoma viruses in kidney transplantation and also analysing humoral immunity against SARS-CoV-2


Teaching Summary

My laboratory hosts undergraduate and graduate students (Masters & PhD students) and welcomes applications from students who wish to undertake their graduate research with us. Similarly, we host and support undergraduate students applying for summer vacation scholarships.

I lecture on the BSc/MSc Molecular Virology, Advanced Virology and Cellular Pathology courses in Infection & Immunity and Fundamentals of Cell Biology (INIM0036).

I am module lead for INIM0010 - Cellular Pathology

I am also the module co-lead and teacher for the Data Interpretation module (INIMG099) delivered on the MSc course in Infection & Immunity

I am the module co-lead for our Infection Journal Club (INIM0037) offered to our 2nd year I&I BSc students 

I am also module co-lead on the Infection & Global Health module delivered as part of an MSc offered by the Faculty of Global Health

Academic Background
2005   Doctor of Philosophy University of Cambridge
2000   Bachelor of Science University of Manchester
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by