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Dr Matthew Reeves
Institute of Immunity & Transplantation
Royal Free Campus
Hampstead
London
NW3 2PF
Tel: 0207794 0500 ext 33109
Appointment
  • Senior Lecturer
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
Biography

PhD: The regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling. University of Cambridge (Profs. Sissons & Sinclair)

Post Doctoral Associate: the anti-apoptotic function of virally expressed untranslated RNA. University of Cambridge (Prof. Sinclair)

Presidential Fellowship: Cellular signalling in HCMV latency and reactivation. Novartis, Massachussets, USA (Prof. Compton)

MRC CDA Fellowship: Impact of cellular signalling and viral gene expression on reactivation of HCMV from latency (University of Cambridge/ UCL)

Senior Lecturer: Institute of Immunity & Transplantation, UCL.

Research Summary

Human Cytomegalovirus (HCMV) remains a major clinical complication in a number of settings including immune-suppressed transplant patients and following congenital infection. The ability of HCMV, like all herpes viruses, to establish a lifelong latent infection of the host results in the threat posed by HCMV as twofold: Transplant patients are at risk following primary infection or following the reactivation of the latent virus that resides in the recipient.


Our group is part of the CMV research group (with Prof Griffiths) and is focused on dissecting the molecular basis of HCMV latency and reactivation, the role of host cell functions during lytic infection, and the identification of determinants of viral pathogenesis in vivo. Questions we are addressing include:


1) The contribution of both viral and cellular functions to viral latency with particular emphasis on how cell signalling pathways are important during both the establishment and reactivation phases of the latent infection.


​2) The natural history of HCMV in solid organ transplant patients. Here the focus is to understand the role of viral genetics and host immunity in the onset of viraemia in these patients with a view to a clearer understanding of why certain individuals are at increased risk of HCMV pathogenesis post transplant.


3) The mechanistic basis of protection afforded by the HCMV gB vaccine. A number of HCMV vaccines have been developed but none are licensed to date. The gB vaccine has shown partial protection in 3 phase II trials and now the challenge is to understand why it was protective and how we can make it better. By extension, we will use this to learn about the role of gB in the entry process of HCMV.


4) The development of novel strategies to target HCMV therapeutically. A major aspect of this approach is to use these as tool compounds to probe the biology of HCMV and gain new insight into the biology of the host:pathogen interaction. One aspect is to utilise an anti-viral approach that empowers a more effective response by the humoral immune system.

 

Teaching Summary

My laboratory hosts undergraduate and graduate students (Masters & PhD students) and welcomes applications from students who wish to undertake their graduate research with us. Similarly, we host and support undergraduate students applying for summer vacation scholarships.

I lecture on the BSc/MSc Molecular Virology, Advanced Virology and Cellular Pathology courses in Infection & Immunity.

I am module lead for INIM3004 - Cellular Pathology

I am also the module co-lead and teacher for the Data Interpretation module (INIMG099) delivered on the MSc course in Infection & Immunity

Academic Background
2005 PhD Doctor of Philosophy – Molecular Virology University of Cambridge
2000 BSc Hons Bachelor of Science – Molecular Biology University of Manchester
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