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Prof Matt Sydes
90 High Holborn (2nd floor)
Other (Non U.S.)
Prof Matt Sydes profile picture
  • Professor of Clinical Trials and Methodology
  • MRC Clinical Trials Unit at UCL
  • Inst of Clinical Trials &Methodology
  • Faculty of Pop Health Sciences

Matt has been Professor of Clinical Trials and Methodology since2019. He started as a Trial Coordinator at the MRC Cancer Trials Office inCambridge in 1995, before training as a statistician and moving into astatistical role. He has been with the unit throughout his career, includingthrough the merger into the MRC Clinical Trials Unit in London in 1999 and themove into UCL in 2013.

Research Groups
Research Themes
Research Summary

Matt is responsible for co-leading the unit's Trial Conduct Methodology programme with the Unit’s Director, Max Parmar. This work is to develop evidence-based ways to improve how clinical trials are run.

Particular areas of interest include: the use of routinely-collected electronic health records (EHR) to support and run trials, with Health Data Research UK; running academic-led trials with a view to regulatory use and submission; proportionate and efficient monitoring of clinical trial; implementation of novel designs into practice, particularly platform / master protocols; better clinical trial data sharing; and communication of trial findings.

Matt chairs the Scientific Committee for ICTMC 2022, the next International Clinical Trials and Methodology Conference, and is on the executive committee for the NIHR-MRC Trials Methodology Research Partnership (TMRP). He sits on several funding panels, including MRC’s Better Methods Better Research.

Matt is 20% seconded to lead the Data-Enabled Trials theme for the BHF Data Science Centre, led by Health Data Research UK.

Teaching Summary

Matt leads UCL's short course on Independent Data MonitoringCommittees (IDMC), building on the DAMOCLES projects and extensive experience servingon external IDMCs and Trial Steering Committees for national and internationaltrials.

He teaches on the UCL Institute of Clinical Trials andMethodology's MSc in Clinical Trials and has supervised many MSc studentprojects.

He supervises a number of PhD students exploring ways toimprove the conduct of clinical trials.

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