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Prof Matt Sydes
Desk 2023
90 High Holborn (2nd floor)
Prof Matt Sydes profile picture
  • Professor of Clinical Trials and Methodology
  • MRC Clinical Trials Unit at UCL
  • Inst of Clinical Trials &Methodology
  • Faculty of Pop Health Sciences

Matt has been Professor of Clinical Trials and Methodology since 2019. He started as a Trial Coordinator at the MRC Cancer Trials Office in Cambridge in 1995, before training as a statistician and moving into a statistical role. He has been with the unit throughout his career, including through the incorporation into the MRC Clinical Trials Unit in London in 1999 and the subsequent incorporation into UCL in 2013.

Research Groups
Research Themes
Research Summary

Matt is responsible for co-leading the unit's Trial Conduct Methodology programme. This work is to develop evidence-based ways to improve how clinical trials are run.

Particular areas of interest include: the use of routinely-collected electronic health records (EHR) to support and run trials, with Health Data Research UK; running academic-led trials with a view to regulatory use and submission; proportionate and efficient monitoring of clinical trial; implementation of novel designs into practice, particularly platform / master protocols; better clinical trial data sharing; and communication of trial findings.

Matt co-leads the trials methodology work in the infrastructure programme of Health Data Research UK. Matt is seconded part-time to lead the Data-Enabled Trials theme for the BHF Data Science Centre, led by Health Data Research UK.  He is on the executive committee for the NIHR-MRC Trials Methodology Research Partnership (TMRP) and co-chairs its Health Informatics Working Group. 

He sits on several funding panels, including chairing the MESSIDORE panel for INSERM in France and the MRC’s Better Methods Better Research panel in the UK.

(Note: many of the other tabs are auto-populate by UCL systems and seem to be missing information about funding, students and projects. Further information can be found via: https://linktr.ee/mattsydes)

Teaching Summary

Matt leads UCL's short course on Independent Data Monitoring Committees (IDMC), building on the DAMOCLES projects and extensive experience serving on, and reporting to, IDMCs and Trial Steering Committees for national and international trials.

He teaches on the UCL Institute of Clinical Trials and Methodology's MSc in Clinical Trials and has supervised many MSc student projects.

He supervises a number of PhD students exploring ways to improve the conduct of clinical trials.

Matt also teaches on a number of international course.

Academic Background
  BSc Hons Experimental Psychology  
  MSc Applied Statistics  
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