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Dr Maria Secrier
UCL Genetics Institute, Darwin Building
Gower Street
Dr Maria Secrier profile picture
  • Lecturer
  • Genetics, Evolution & Environment
  • Div of Biosciences
  • Faculty of Life Sciences

I'm a Lecturer (Assistant Professor) in Computational Biology at the UCL Genetics Institute in the Department of Genetics, Evolution and Environment. My research focus is genomic instability and tumour-immune crosstalk during cancer progression.

I received my bachelor's degree from Jacobs University (Bremen, Germany) and my PhD from the European Molecular Biology Laboratory (EMBL, Heidelberg) and the University of Heidelberg (Germany). Following my PhD I worked on the genomics of oesophageal cancer as a Research Associate at the Cancer Research UK Cambridge Institute, and on the identification of new targets and immuno-oncology as a Senior Scientist at AstraZeneca.

Research Summary

My research interests lie in understanding the evolution of genomic instability during cancer development and progression, and how this links to changes in the tumour microenvironment and impacts immune responses. I aim to address this by developing new computational methods for the identification of large-scale events contributing to genomic instability, probabilistic models that link genetic changes and immune activity, and methods for inferring the timing and genetic features of key points in cancer progression. A strong focus on the group is employing machine learning and data integration strategies in a multi-omics context.

I have recently started to explore the neurobiology field as well, in view of applying methods from the cancer field in the area of neurodegenerative diseases.

Please visit the lab website for more information on the research performed in my group: https://secrierlab.github.io/

Teaching Summary

  • Chair of Genetics and Human Genetics undergraduate degrees.
  • Module organizer and lecturer for Advanced Computational Biology (UCL)
  • Lectures delivered in Cancer Genetics within the MSc in Human Genetics (UCL)
  • Acted as supervisor (tutor) in Mathematical Biology (Natural Sciences) at the University of Cambridge (2 years)
  • Several lectures and tutorials delivered in the past at the University of Luxembourg, European Molecular Biology Laboratory (EMBL), Jacobs University (Germany)

11-JUL-2016 – 06-OCT-2017 Senior Scientist Oncology Bioinformatics AstraZeneca, Cambridge, United Kingdom
01-JUL-2016 – 01-JUL-2017 Visiting Scientist Statistics and Computational Biology Cancer Research UK Cambridge Institute, United Kingdom
01-OCT-2014 – 30-SEP-2016 Bye Fellow Mathematical Biology (NatSci), Murray Edwards College University of Cambridge, United Kingdom
04-JAN-2014 – 30-JUN-2016 Research Associate Statistics and Computational Biology Cancer Research UK Cambridge Institute, United Kingdom
01-JUL-2013 – 01-NOV-2013 Short-term Postdoctoral Fellow Structural and Computational Biology European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
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