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Dr Manjit Matharu
Queen Square
London
London
WC1N 3BG
Tel: 08451 555000
Fax: 0207 829 8784
Appointment
  • Clinical Senior Lecturer
  • Brain Repair & Rehabilitation
  • Institute of Neurology
  • Faculty of Brain Sciences
Research Themes
Research Summary
Functional imaging studies had previously demonstrated specific activation of the brainstem in episodic migraine and the posterior hypothalamus in cluster headache (CH). The studies by the Headache Group helped further refine the localisation of the brainstem activation in episodic and chronic migraine to the dorsal rostral pons using positron emission tomography (PET) and demonstrated that lateralisation of pain in migraine is due to lateralised brain dysfunction. We also studied cerebral activation patterns in paroxysmal hemicrania (PH) and short lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT), which along with CH are grouped together as trigeminal autonomic cephalalgias. Significant activation of the posterior hypothalamus and ventral midbrain region was demonstrated in PH using PET while posterior hypothalamic activation was demonstrated in SUNCT using functional magnetic resonance imaging. In a PET study in hemicrania continua (HC), the clinical phenotype of which overlaps with migraine and the trigeminal autonomic cephalalgias, we demonstrated significant activation of the posterior hypothalamus, dorsal rostral pons and ventrolateral midbrain. These series of studies suggested that primary headache may be pathophysiologically differentiated on the basis of distinct patterns of brain activation, with hypothalamic and dorsal pontine activation as markers of trigeminal autonomic cephalalgias and migrainous syndromes, respectively. These studies draw attention to the structures that may play a pivotal role in the pathophysiology of primary headaches. The classification and clinical spectrum of headache disorders have hitherto been poorly defined though large strides have been made in this area over the last two decades. We has accumulated relatively large cohorts of various headaches syndromes and systematically studied their clinical phenotypes.
Academic Background
2006 PhD Doctor of Philosophy – Brain Sciences University College London
1999 MRCP Member of the Royal College of Physicians Royal College of Physicians
1994 MB.ChB Bachelor of Medicine, Bachelor of Surgery – Medicine University of Manchester
1991 BSc Bachelor of Science – Cell Physiology and Pharmacology University of Manchester
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