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Dr Nuria Seto-Salvia
1st floor
1 Wakefield Street
Queens Square Brain Bank, Institute of Neurology
United Kingdom
  • Research Associate
  • Clinical and Movement Neurosciences
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences
Research Themes
Research Summary

Dr Núria Setó-Salvia, a Spanish Postdoctoral Neuroscientist with a strong background in the genetics of neurodegenerative diseases. Núria has taken up the challenge of investigating the molecular biology of tau mutations in frontotemporal dementia and corticobasal degeneration (CBD). Corticobasal degeneration is known as a ‘tauopathy’ in which different types of cells in the brain progressively die due to abnormal accumulation of the protein tau. Skin cells from people with a genetic mutation in their DNA that leads to a condition with similar clinical and pathological features to CBD are taken. Dr Setó-Salvia then manipulates these cells to become brain cells, producing a model of disease that can be grown in a culture dish in the laboratory to replicate what is happening in the brain. The project utilises a range of experimental scientific methods to compare the cellular mechanisms of CBD patients with those of healthy individuals, in an attempt to explain why the abnormal tau protein makes brain cells vulnerable and leads to their death. Understanding these changes could aid the development of new drugs to reverse these defects and thereby halt or slow the progression of the disease. In the longer term pluripotent stem cells also hold great promise in the field of regenerative medicine, as they may allow replacement of damaged or dead brain cells with those developed in culture.

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