I am a Neurology registrar and PhD student on the Francis Crick Clinical Fellow programme. I am supervised by Prof Rickie Patani and Prof Nick Luscombe. I am using computational techniques to examine how RNA processing breaks down in astrocytes and motor neurons in Amyotrophic Lateral Sclerosis (ALS). I utilise a stem cell model (iPSC) of human ALS astrocytes and motor neurons, to understand how changes in RNA processing (alternative splicing and polyadenylation) cause this disease. Through this I am trying to identify the earliest molecular detectable change in ALS in order to expose a viable therapeutic avenue.