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Dr Oliver Ziff
Appointment
  • Crick-NIHR UCLH BRC Doctoral Fellow
  • Department of Neuromuscular Diseases
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences
Biography

Obtained BSc (in Physiology, 1st Class, 2011), MBChB (Honours, 2014) from Birmingham Medical School and MRCP in 2016. Completed NIHR Academic Foundation Programme at University College London 2014 - 2016. Completed NIHR Academic Clinical Fellowship in Neurology at University College London in 2016 - 2019. Since 2019 I have been undertaking a PhD on the Crick Clinical Fellow Programme. 

Research Themes
Research Summary

I am a Neurology registrar and PhD student on the Francis Crick Clinical Fellow programme. I am supervised by Prof Rickie Patani and Prof Nick Luscombe. I am using computational techniques to examine how RNA processing breaks down in astrocytes and motor neurons in Amyotrophic Lateral Sclerosis (ALS). I utilise a stem cell model (iPSC) of human ALS astrocytes and motor neurons, to understand how changes in RNA processing (alternative splicing and polyadenylation) cause this disease. Through this I am trying to identify the earliest molecular detectable change in ALS in order to expose a viable therapeutic avenue. 

Teaching Summary

I deliver lectures on a national preclinical basic science course and I write cases for national question banks. I also deliver clinical skills teaching at the bedside and help guide candidates preparing for the MRCP PACES examination.

Appointments
01-AUG-2019 Crick Clinical PhD Programme Institute of Neurology UCL & Francis Crick Institute, United Kingdom
01-AUG-2016 – 31-JUL-2019 Academic Clinical Fellowship Institute of Neurology UCL, United Kingdom
01-AUG-2014 – 31-JUL-2016 Academic Foundation Programme Institute of Cardiovascular Science UCL, United Kingdom
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