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Dr Pierre Klein
Room 511
Darwin Building
Gower Street
London
WC1E 6XA
Appointment
  • Research Fellow
  • Structural & Molecular Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Biography

Pierre is a French doctor in molecular and cellular biology with a passion for RNA metabolism. He has been specialising his research on this topic together with studying genetic diseases and developing gene and cell therapies. Pierre led multiple research projects and received several competitive prizes and fellowships. 


Pierre was awarded his Ph.D. in September 2016 from the University of Pierre and Marie Curie in Paris. He performed his research at the Myology Centre for Research in the laboratory of Capucine Trollet and Vincent Mouly, where he worked on a rare genetic muscular dystrophy caused by a mutation in PABPN1, an RNA-binding protein involved in post-transcriptional RNA regulation. 


After his Ph.D., Pierre joined the laboratory of Samie R. Jaffrey at Weill Medical College in New York City where he led a project on the role of m6A RNA modification in stress granule formation and the ability of YTHDF proteins to undergo liquid-liquid phase separation.


Pierre took a business and management training with INSEAD school in Paris to expand his expertise and knowledge in a different domain.

Research Summary

Pierre joined the Ramos lab at the end of March 2019, where he has been studying the role of IMP proteins on RNA transport and local translation in neurons. A critical layer of gene expression in polarised cells like neurons is the translation of RNA molecules in a temporally but also spatially regulated manner. By accomplishing this project, Pierre expects to better comprehend this complex mechanism. It should also pave the way to a better understanding of the biology behind synaptic development and differentiation as well as pathological mechanisms present in neuronal diseases. Pierre will be using cutting-edge technologies to look at single-molecule localisation (MERFISH) and protein-RNA interaction at nucleotide resolution (IClip).

Teaching Summary

Teaching Assistant - Library of Pierre and Marie Curie University, Paris – 2013-2016

  • Teaching methodology of documentary and bibliographic research (pubmed, WoS, eg)
  • Teaching assessment of information found on the web 
  • Preparing written materials
  • Explaining complex concepts
  • Mentoring students
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