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Prof Patrick Lewis
Prof Patrick Lewis profile picture
  • Honorary Associate Professor
  • Neurodegenerative Diseases
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences
I studied biochemistry at the University of Manchester, undertaking a year of research at the Mayo Clinic in Florida as part of this during which I investigated cellular dysfunction linked to mutations in the amyloid precursor protein and presenilin 1 associated with familial Alzheimer's disease. I then moved to the MRC Prion Unit at UCL, where I carried out graduate studies into the molecular mechanisms of scrapie gaining my PhD in 2005. From 2005 to 2007 I was visiting fellow in the Laboratory of Neurogenetics at the National Institute of Aging in Bethesda, mentored by Mark Cookson. It was here that I first started working on LRRK2, a protein which has been the object of my affections ever since. I returned to UCL in 2007 as a Brain Research Trust senior research fellow in the Department of Molecular Neuroscience and have continued my research into the basis of Parkinson's disease linked to mutations in LRRK2. I am currently a Parkinson's UK research fellow.
Research Summary
My research concentrates on characterizing the biological insults leading to cell death in inherited forms of Parkinsonism linked to mutations in LRRK2. We are using a range of experimental approaches to examine the impact of mutations both on the biochemistry of these proteins, their folding and activities, and on the cell biology of neuronal cells. Our aim is to generate a comprehensive overview of the structure/function/phenotype of LRRK2, linking this in to the pathologies observed in patients.

Techniques used include cell and primary culture,  kinase and GTPase analysis, circular dichroism spectropolarimetery, analytical ultracentrifugation.

Teaching Summary
I am a module convener on the MSc in Clinical Neuroscience here at Queen Square, involved in organising the course, lecturing and acting as a tutor.
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