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Mr Patrick Arnott
2.04, Bernard Katz, UCL
Malet Place
London
WC1E 6BT
Appointment
  • EPSRC Doctoral Prize Fellowship
  • Dept of Biochemical Engineering
  • Faculty of Engineering Science
Research Themes
Research Summary

My research is focused on developing early stage diagnostics for infectious diseases. Utilising microfluidics and DNA nanotechnology to develop rapid diagnostics (less than 20 minutes) for a range of targets from highly infectious human to veterinary diseases.

A platform technology based on microfluidic methods can enable significant automation of more complex assay formats but there is a need for approaches to rapidly and effectively concentrate targets of interest from patient samples for detection in simple, label-free assays formats

Combination of microfluidics with DNA nanotechnology and aptamers presents an ideal form of target binding molecule capable of label-free sensing. The rapidly growing area of DNA nanotechnology allows for synthetic molecules which have specificity and affinity on par with mAbs, but have the added ability to be generated against any target including non-immunogenic, small molecule, toxic or bacterial infections.

A vital benefit of aptamers is the versatility of their use for all biomarkers, making the aptamer microfluidic approach ideal for large scale outbreak response. Where it is essential to stockpile diagnostics that are: low cost, quick, stable and easy to use with simple machinery and no expertise requirements a multiplatform technology based on aptamers provides the solution.


Academic Background
2019   Biochemical Engineering University College London
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