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Dr Preethi Sheshadri
Cell and Developmental Biology Department
Division of Biosciences, University College London
Dr Preethi Sheshadri profile picture
  • Research Associate
  • Cell & Developmental Biology
  • Div of Biosciences
  • Faculty of Life Sciences

An enthusiastic researcher, a student of science with an appetite to learn and contribute in the field of cell biology, mitochondria and neuroscience, I’ve done my doctoral work studying the effects of mitochondrial Manganese Superoxide dismutase (MnSOD) in Embryonic Stem cells under the guidance of Dr. Anujith Kumar at School of Regenerative Medicine (SORM), Manipal University, India .

With a short stint as a postdoc in Rutgers University, NJ, USA in Dr. Qian Cai’s lab between 2017 and 2017, where I studied Axonal mitophagy in Alzheimer’s disease in primary Cortical Neuron Cultures and Brain slices using J20 and Tauopathyanimal models, I’m now working with Prof. Michael Duchen in his lab atthe University College London, since March 2019 studying  the effects of GBA1 mutations on Parkinson’s Disease, using human patient derived iPSCs as a model system.

Research Summary

As a cell biologist, I’ve always been interested in cellular and molecular functions affected in neurodegeneration. Mitochondria are one of the first organelles to get affected during neurodegeneration. This sparked an interest in me to learn and understand role of mitochondria and and it’s physiology in neurodegeneration and ageing.

In Prof. Michael Duchen’s lab, I’m working towards understanding the pathophysiology of GBA1-mediated Parkinson’s Disease using patient derived Stem cells(iPSCs) as model system. We differentiate iPSCs into Dopaminergic neurons – the cell type that is primarily affected in Parkinson's patients, and ask questions as to what happens to Mitochondria and what is the autophagic state in this Parkinson's Disease model.

The long term goal of the project is to understand how a number of disordered pathways intersect to drive the pathophysiology of the disease, and so to develop a unifying model of Parkinson's Disease.

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