I head the Lipid Subgroup within the Centre for Cardiovascular Genetics, in the newly formed Institute of Cardiovascular Science. The focus of the work has been the study of genes involved in lipid metabolism and their contribution to heart disease risk. Initial studies were carried out to compare the effect of genetic variation at the apoE, apoB, AI-CIII-AIV-AV and lipoprotein lipase loci on variation in lipid levels in the general population, focusing on interaction with environmental modulators. More recently the studies have diversified to test, both in vivo and in vitro, the molecular mechanisms of specific mutations identified in these and other candidate genes using prokaryotic and tissue culture expression systems. We are now testing the efficacy of using genetic information for CHD calibration, precision and risk prediction. We are part of UCLEB, a consortium formed including researchers from  UCL/Edinburgh and Bristol to bring together the large prospective studies that together number >30,000 individuals followed for 10-30 years. These studies are richly phenotyped and we have used both the 50K Cardiochip and 200K Metabochip to genotype these studies. We are using a gene score approach to examine the association with Cardiovascular risk factors and events.
I also have an interest in Gene Ontology and have a small group working with me annotating genes involved in Cardiovascular Processes, funded by the British Heart Foundation.