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Prof Pavel Tolar
Room 310
Institute of Immunity and Transplantation, Pears Building
Rowland Hill Street
London
NW3 2PP
Tel: +44 20 3987 2444
Prof Pavel Tolar profile picture
Appointment
  • Professor
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
Biography

Pavel Tolar obtained an MD degree at Charles University in Prague, Czech Republic, and a PhD in immunology at the Institute of Molecular Genetics in Prague, where he studied the activation of mast cells.

In 2003, he joined the National Institutes of Health, Rockville, Maryland, USA, as a postdoctoral fellow to work with Susan Pierce on the development of live-cell imaging technology for the study of intracellular B cell signalling pathways.

In 2009, he moved to the MRC National Institute for Medical Research as a programme leader in the Division of Immune Cell Biology to work on the structural, molecular and cellular mechanisms of antigen-mediated B cell activation.

He was awarded the EMBO Young Investigator Award in 2013 and became a group leader at the Francis Crick Institute in 2015.

Pavel Tolar joined UCL as a Professor of B Cell Immunology in 2021.

Research Themes
Research Summary

The Tolar lab investigates B cells to find new ideas for vaccines and therapies of immune diseases.

 

B cells are white blood cells that roam the body ready to react to harmful substances and pathogens, such as viruses and bacteria. They make antibodies that protect us from these invaders. Unfortunately, B cells can also overreact and cause autoimmune disease, allergy or lymphoma.

 

Our lab is interested in B cell triggering, the process by which B cells recognise invaders. We use a range of approaches such as immunology, genetics, biophysics, imaging and nanotechnology to provide an understanding of the molecular processes by which B cells bind foreign materials and mediate immune protection. We also investigate the genes and pathways that are involved in human B cell diseases. We believe that a better understanding of B cell triggering can inform the development of next-generation vaccines and discover targets to eliminate diseased B cells.

 

Teaching Summary

INIM0006 Immunology in Health and Disease

INIM0040 Fundamental and Applied Immunology

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