Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Prof Pavel Tolar
Room 310
Institute of Immunity and Transplantation, Pears Building
Rowland Hill Street
Tel: +44 20 3987 2444
Prof Pavel Tolar profile picture
  • Professor
  • Div of Infection & Immunity
  • Faculty of Medical Sciences

Pavel Tolar obtained an MD degree at Charles University in Prague, Czech Republic, and a PhD in immunology at the Institute of Molecular Genetics in Prague, where he studied the activation of mast cells.

In 2003, he joined the National Institutes of Health, Rockville, Maryland, USA, as a postdoctoral fellow to work with Susan Pierce on the development of live-cell imaging technology for the study of intracellular B cell signalling pathways.

In 2009, he moved to the MRC National Institute for Medical Research as a programme leader in the Division of Immune Cell Biology to work on the structural, molecular and cellular mechanisms of antigen-mediated B cell activation.

He was awarded the EMBO Young Investigator Award in 2013 and became a group leader at the Francis Crick Institute in 2015.

Pavel Tolar joined UCL as a Professor of B Cell Immunology in 2021.

Research Themes
Research Summary

The Tolar lab investigates B cells to find new ideas for vaccines and therapies of immune diseases.


B cells are white blood cells that roam the body ready to react to harmful substances and pathogens, such as viruses and bacteria. They make antibodies that protect us from these invaders. Unfortunately, B cells can also overreact and cause autoimmune disease, allergy or lymphoma.


Our lab is interested in B cell triggering, the process by which B cells recognise invaders. We use a range of approaches such as immunology, genetics, biophysics, imaging and nanotechnology to provide an understanding of the molecular processes by which B cells bind foreign materials and mediate immune protection. We also investigate the genes and pathways that are involved in human B cell diseases. We believe that a better understanding of B cell triggering can inform the development of next-generation vaccines and discover targets to eliminate diseased B cells.


Teaching Summary

INIM0006 Immunology in Health and Disease

INIM0040 Fundamental and Applied Immunology

INIM0003 Data Interpretation in Immunology

INIM0010 Cell Pathology

Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by