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Dr Rina Bandopadhyay
104
Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology
1, Wakefield Street
London
United Kingdom
WC1N 1PJ
Appointment
  • Senior Research Fellow
  • Molecular Neuroscience
  • Institute of Neurology
  • Faculty of Brain Sciences
Biography

After completing my PhD from Charing Cross and Westminster Medical School (currently Imperial College) in 1995 I joined Department of Molecular Endocrinology at UCL. I joined Reta Lila Weston Institute of Neurological Studies, UCL in 1998. Initially I worked on molecular aspects of stroke but then I  shifted my interest to Parkinson's Disease (PD) research under the directorship of Professor Andrew Lees. Currently I am working with Professor Tom Warner, current director of RLWI and continuing my investigations on PD especially LRRK2 associated PD. 

Research Groups
Research Themes
Research Summary

For the past ten years I have been involved in research on Molecular mechanisms of Parkinson's disease (PD) and other movement disorders and also familial British dementia. Using human brain tissue at the Queen Square Brain Bank, ION, I have been investigating the Park loci proteins in the pathogenesis of Parkinson's disease. I was the first to localise DJ-1 protein expression in human brain at tissue level and reported that the major cell type expressing DJ-1 was astroglia in cortex and nigra. In addition I demonstrated that the normal function of DJ-1 may be compromised in the PD brain (Bandopadhyay et al, Brain, 127, 803) and that it is sensitive to oxidative stress. Investigations on the functional aspects of DJ-1 protein in human brain have shown that DJ-1 protein co-localises with fibrillar tau in tauopathies and is suggestive of a chaperone-type function for DJ-1 in these diseases. My current research is to localise LRRK2 in human brain tissue using MJFox antibodies and understand the molecular basis of LRRK2 mediated neurodegeneration. Currently my research plans incorporate use of human iPS cells for studying the pathogenic basis of LRRK2 mutations. 

Recently I have also developed an interest on the pathogenic basis of frontotemporal dementias. In particular I am interested in the role of RNA granules (Stress granules and P-bodies) in disease pathogenesis. 

Teaching Summary

I have successfully supervised PhD students. 

Since 2004, I have regularly supervised Neuroscience BSc, Neuroscience MSc and Clinical Neuroscience MSc projects. 

I am also involved with module 1 teaching for Clinical Neuroscience students at UCL Institute of Neurology. 

Academic Background
1995 PhD Doctor of Philosophy – Neuroscience University of London
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