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Prof Robin Callard
Institute of Child Health
30 Guilford St
Tel: 0207 813 8493
Fax: 0207 813 8494
  • Emeritus Professor
  • ICH Infect, Imm, Infla. & Physio Med
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences
Research Summary
My research for the past 20 years has been directed at understanding the complex cellular interactions of the human immune system. I am currently involved in three continuing research programmes. One is with Professor Nigel Klein using in vitro methods to measure human immune responses to meningococcal bacteria with the aim of developing whole bacteria vaccines. The second is with Professor John Harper on the skin barrier and allergy. Our work has led us to propose that the increased incidence of allergy in the developed world may result from loss of skin barrier function through excessive washing and use of "skin care" products. My third major research programme is on mathematical modelling of the immune system including the cytokine network, homeostatic control of T cell populations in HIV, transcription factor control of Th1 and Th2 differentiation and p53 regulation of apoptosis using a novel mathematical method for predicting transcription factor gene targets. I have international collaborations with Dr Andrew Yates, Department of Biology, Emory University, Atlanta, USA on T cell homeostasis and HIV; Dr Rodolphe Thiebaut, INSERM U875 Biostatistics, ISPED at the University of Bordeaux on modelling T cell homeostasis and the generation of immunological memory; Professor James Sneyd and Dr Gib Bogle at the University of Auckland, New Zealand on mathematical modelling of T cell activation and migration in lymph nodes.
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