My research combines clinical observations with laboratory approaches to better understand the molecular basis and pathophysiological mechanisms of primary mitochondrial diseases, with the ultimate aim of developing treatments. My laboratory focuses on three major research themes that crosscut mitochondrial biology and translational science. These include: 1) Establishing the global prevalence and genetic architecture of mitochondrial diseases; 2) Understanding the role of cardiolipin in mitochondrial health and disease; and 3) Generating effective therapies for mitochondrial diseases.