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Prof Robert Unwin
Centre for Nephrology, Royal Free Campus
Rowland Hill Street
Tel: 0044 207 472 6499
Fax: 0044 0207 472 6476
Prof Robert Unwin profile picture
  • Emeritus professor
  • Div of Medicine
  • Faculty of Medical Sciences
Research Groups
Research Themes
Research Summary
Most aspects of renal and gastrointestinal transport physiology, especially in a clinical context. These include regulation of potassium and acid-base transport, with relevance to renal 'tubulopathies' and renal stone disease; gut phosphate and glucose absorption in health and disease.
Methods of studying renal tubular function, including micropuncture and microperfusion techniques, and developing ultramicroanalytical methods to facilitate the application of these techniques.
Analytical methods include proteomics, NMR, and mid-infrared spectroscopy as applied to the kidney in biomarker detection and in tubular diseases, e.g., the renal Fanconi syndrome.
Three main themes at present are:
(1) The function of the renal P2 purinoceptor system; its role in transport regulation and some forms of renal disease.
(2) Humoral control of gastrointestinal transport of phosphate and its relationship to changes in renal function.
(3) Renal glucose transport in diabetes.
Teaching Summary
I teach medical (and science) undergraduates and postgraduates, and I run an annual national course in applied renal physiology and pathophysiology for clinical postgraduate trainees and interested specialists.
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