My research has focussed on structural MR imaging in neurodegenerative diseases. I have developed methods for automated image analysis and applied these to aid the early detection of neurodegeneration in the brain and to monitor disease progression over time. These techniques have demonstrated brain atrophy several years prior to symptom onset in gene carriers of Alzheimer’s disease (AD) and Huntington’s disease (HD). Ultimately, I hope these tools will be used as outcome measures to assess therapeutic efficacy in future clinical trials. I am currently working on the TREAT-HD study, a Wellcome Trust funded project to investigate mechanisms of neuronal recovery following treatment as well as identify the ideal time window to administer therapies.