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Prof Reecha Sofat
Room 106
222 Euston Road
  • Professor of Clinical Pharmacology
  • Clinical Epidemiology
  • Institute of Health Informatics
  • Faculty of Pop Health Sciences
UCL Principal Supervisor,UCL Subsidiary Supervisor
Research Summary

Reecha Sofat is a Clinical Pharmacologist practising general internal medicine, cardiovascular risk and stroke as a sub-speciality.

Her group is interested in harnessing routinely collected health care data to improve quality and safety of care but also to be able to generate knowledge and hypotheses by linking this information to next generation –omics technologies. The aim is that this will improve outcomes not only for individuals but also will be of public health benefit. 

She is the PI of a group of studies, CORUM that aims to embed research into routine health care. By nature clinical care phenotypes patients and the sub-types of disease in great detail, be it through the written clinical record, routine blood tests and imaging that are carried out. Linked to next generation technologies including genomics, transcriptomics, proteomics and metabolomics these data could allow understanding aetiology of disease and specifically sub-types of disease. Moreover, because this research is embedded within the health care system, linking these data to the NHS number allows long term follow up and establishment of prognostic cohorts. The scale allows generation of knowledge that is of public health value and the focus on disease sub-types linked to next generation technologies allows precision medicine to become a reality. This framework will facilitate the next generation of randomised controlled trials for disease sub-types, but importantly by feeding this information back into the health care system it aims to improve the quality and safety of care of patients now and in the future. The first of the studies, SIGNUM, focuses on stroke. This is currently the highest recruiting study nationally. Other studies will focus on heart failure (CARDIUM), atrial fibrillation (ATRIUM), venous thromboembolism (COAGULUM) and conditions that may be related to vascular outcomes (VASCULARUM). These will open in early 2018.

By nature the work is multi-disciplinary and includes collaborations with clinical services and scientist, health care delivery organisations, epidemiologists, computational biology and engineering amongst others

Teaching Summary

She is the lead for the MBBS Uses of Medicines Spine at UCL, spanning undergraduate basic pharmacology teaching to clinical therapeutics teaching.

Academic Background
2006   Master of Science London School of Hygiene and Tropical Medicine
2001   Member of the Royal College of Physicians Royal College of Physicians
1998   Bachelor of Medicine/Bachelor of Surgery University College London
1995   Bachelor of Science (Honours) University of London
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