My research theme is focussed on neuromuscular disorders, neurodegenerative disorders, and neurogenetics. Within neuromuscular disorders I am interested in motor neuron disease / amyotrophic lateral sclerosis, muscular dystrophies, neuropathies, and related conditions. Current research projects include mitochondrial function in ALS, the neurotrophic effects of mechanogrowth factor (MGF) in ALS and other disorders, and genetic analysis of ALS. In addition to laboratory research, I provide a clinical service in neuromuscular disorders, including my role as Co-Director of the Motor Neuron Disease Care and Research Centre at the National Hospital for Neurology and Neurosurgery, and motor neuron disease, muscle and nerve disorder clinics at the Royal Free Hospital. I perform muscle and nerve biopsies, and EMG, and contribute to the reporting of peripheral nerve biopsies. As co-lead for motor neuron disease in the North Thames Department of Health funded Dementia and Neurodegenerative Diseases Research Network (DeNDRoN), I am developing a structure for clinical and other research projects. I am lead of the UCL Motor Neuron Disease Research Interest Group.