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Prof Steve Brocchini
Appointment
  • Professor
  • Pharmaceutics
  • UCL School of Pharmacy
  • Faculty of Life Sciences
Biography

Steve has a BA (Reed College, Portland, OR, USA) and a PhD (University of Michigan, Ann Arbor, MI, USA) in chemistry. After a postdoctoral (Emory University, Atlanta, GA, USA) he came to the UK to work as a medicinal chemist (Xenova Ltd, Slough).  Steve then worked as an adjunct faculty member (Rutgers University, Piscataway, NJ, USA) in polymer chemistry and tissue engineering.  Steve joined the UCL School of Pharmacy in late 1997.

Research Summary

Our research is multi-disciplined, collaborative and clinically driven.  All projects are hypothesis driven and most projects have a stated clinical translational goal. PhD students typically work on a project that is jointly supervised with a collaborator from another area of science. Most students will work in at least two laboratory environments. Projects tend to address three key themes: (i) to optimise pharmacokinetics, (ii) to ensure a conjugate, dosage form or device is stable and (iii) to conduct research that is scalable so there is a plausible pathway for clinical translation.


During the last decade, projects have covered solid dispersions, pulmonary dry powders, particle coating, polymer-drug conjugates and development of degradable biomaterials. More recent research has focused on protein-PEGylation, development of polyvalent medicines, development of soluble polymer-drug complexes and ocular delivery. Current projects are focused in areas that include (i) chemical-recombinant approaches to develop multifunctional therapeutic proteins, (ii) formulation of protein therapeutics into novel dosage forms, (iii) development of computational pharmaceutics and (iv) new strategies in ocular drug delivery.

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