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Prof Snezana Djordjevic
Darwin Bldg.
Gower Street
Tel: 020 7679 2054
Prof Snezana Djordjevic profile picture
  • Professor of Structural Biology of Signalling
  • Structural & Molecular Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Research Summary

My research always included multitude of different techniques such as enzymatic studies, ITC and UV/VIS spectroscopy, molecular modelling, and site-directed mutagenesis that complemented X-ray crystallographic analysis of the proteins of interest. Following my PhD, I worked as a Howard Hughes Medical Institute research associate in the laboratory of Ann Stock that was investigating bacterial signal transduction proteins regulating bacterial chemotaxis. I solved crystal structures of receptor methyltransferase, methylesterase and methyltransferase in complex with the C-terminal receptor peptide. In 1998 I moved to UK and after a short career break I spent a year as a post-doctoral research scientist at MRC-LMB. Since 2000 I am at UCL where, capitalizing on my experience in methylation/demethylation regulation of bacterial chemotaxis receptors I developed a research in methylation regulation of eukaryotic signal-transduction protein + protein phosphatase PP2A. At the same time as a result of collaborations with Prof Ortiz de Montellano from UCSF and Prof Kelly and Dr Wilkinson from London School of Hygiene & Tropical Medicine, I have developed research in molecular basis of various pathogens oxidative stress defense mechanisms. We have solved a crystal structure of wild type and several catalytic-site specific mutants of AhpD from M. tuberculosis. This enzyme with unique folding topology and thioredoxin-like activity supports AhpC catalyzed reduction of ROSs in Mtb. In conjunction with this project we are also studying unique peroxidases from T. cruzi, and we have recently solved a crystal structure of GPXI from this organism.

Currently my laboratory is engaged in both basic and translational research involving signalling in prokaryotes and human systems.   We instigated structural, mechanistic and comparative genomics of two-component regulatory systems in M. Tuberculosis and, in collaboration with Dr J. Santini, NT-26 - an arsenite utilising bacterium.  At the same time, through industrial and academic collaborations, we are engaged in providing structural and biophysical support for the specific drug-discovery programmes targeting human transmembrane receptors implicated in cancer and cardiovascular diseases. 

Teaching Summary

Module organizer for BIOC0008 Biomolecular Structure and Function module.

Academic Background
2002   ATQ01 - Successfully completed an institutional provision in teaching in the HE sector University College London
1994   Doctor of Philosophy Medical College of Wisconsin
1987   Bachelor of Science Univerziteta u Nisu
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