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Dr Sonam Gurung
30 Guilford Street
Dr Sonam Gurung profile picture
  • Research Fellow
  • Genetics & Genomic Medicine Dept
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences

I am a postdoctoral fellow at UCL (GGM, GOS ICH), currently investigating efficacy of mRNA therapy in Argininosuccinic lyase (ASL) deficiency, a urea cycle enzyme. I am furtherinvestigating mechanisms underlying disease pathology in ASL and expanding my expertise to other UCDs such as ASS deficiency. I have previously worked with exosomes as a therapeutic delivery system in ASL deficiency. 

During my PhD, I investigated the synaptic roles of Kainate receptor, a glutamate receptor at University of Bristol (Department of Biochemistry), using primary cultured neurones implementing biochemical techniques. My work was particularly focussed on understanding the roles of RNA editing on Kainate receptor plasticity. I also performed work on protein level changes during various stages of epilepsy. 

I successfully applied for 9 month fellowship, EBI Postgraduate hopping fellowship,  at University of Bristol (Department of Physiology, Pharmacology and Neuroscience) after my PhD where I trained on and implemented electrophysiological techniques on mouse brain slices to study the synaptic effect of RNA editing at MF-CA3 synapses.  

Research Themes
Research Summary
My research is focussed on investigating novel therapies in urea cycle defects (UCD) and understanding mechanisms underlying disease pathology in UCDs.

Novel therapies include protein therapy using exosomes and mRNA therapy using lipid nanoparticles.

Teaching Summary
-Co-module lead in ICH Masters modules: Clinical Genomics, Genetics and Rare diseases (CHLD0066) and Novel Therapies (CHLD0091).

-Supervision of summer student projects. 

-Experience in Masters thesis marking. 

05-AUG-2019 Postdoctoral researcher Genetic Genomics and Medicine GOS ICH, UCL, United Kingdom
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