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Dr Spyros Manolopoulos
Dr Spyros Manolopoulos profile picture
  • Senior Research Fellow
  • Dept of Med Phys & Biomedical Eng
  • Faculty of Engineering Science

My professional career started working as Research Associate in Glasgow University following my graduation with a PhD in elementary particle physics at the University of Sheffield. Following a tenure position as a Senior Scientist in the Rutherford Appleton laboratory, I joined the NHS and became a Clinical Scientist and Medical Physics Expert in Radiotherapy (RT). I worked at various hospitals as a Consultant Clinical Scientist or Head of Radiotherapy Physics acquiring an extensive experience in leading multidiscipline clinical teams of healthcare professionals. I have set up the vision for the clinical RT service and  advised hospital executive boards in the specification and procurement of capital RT equipment, planned and oversaw staff recruitment their training and continuous development, managed the physics team, co-founded an academic research group, formed clinical partnerships, lobbied politicians and industrialist promoting RT issues and spoke publicly about radiotherapy and scientific research. I planned and managed a safe, efficient and resilient radiotherapy physics service that incorporated leading edge technology, achieving: 

  • The clinical implementation of advanced treatments (IG-IMRT, SABR, SGRT).
  • Cost savings on UHCW’s capital RT equipment lifecycle program of ca. £4M.
  • Increased productivity by eightfold enabling UHCW to meet the national IMRT target. 
  • The formation of a regional strategic partnership (between UHCW and WAHT) that resulted in innovative collaborative working and joint governance to promote best practice, increase service efficiency and quality.
  • A shared vision with the clinical consultants and Trust managers. 
  • Staff “buy in” and increased engagement of my teams as measured in staff surveys. 
  • A record number of contributions to a major national scientific conference (UKRO 2015) by UHCW’s RTP team.
  • The foundation of a national scientific network to promote advances in RT (https://www.advanced-radiotherapy.ac.uk/). 
  • Over £3M in research funding. 
I have thirty six (36) papers, as main or co-author, published in peer reviewed journals with impact factors ranging from 0.885 to 5.409, which have been cited over three hundred (300) times by other researchers. I have contributed to a scientific textbook and edited a special issue in a peer reviewed international journal. I am panel member for the external assessment of academic departments at Greek Universities, have been a member of professional bodies (IoP, IPEM) including IoPs Medical Physics committee. I have received various honorary clinical\academic appointments, including an associate professorship (University of Warwick). 

Research Summary

My research interests include all aspects of radiotherapy physics, from treatment planning to delivery with photons or protons and the development of the associated instrumentation. I have worked on the knowledge transfer of particle physics detector technology to medical applications, having invented position sensitive instruments to measure the dose deposited by ionising radiation during stereotactic radiosurgery treatments, as well as the patient volumetric imaging with protons for proton Computed Tomographic (pCT) imaging. These I am keen to pursue further with a new project to develop an instrument for the measurement of the range of protons used in proton beam therapy (PBT), soon to become available at UCLH. The initial aim is assist the quality assurance tests prior to PBT patient treatments, leading eventually to the real time monitoring of PBT treatments in vivo

My other research focus is the development of a clinical trial to study the feasibility of Biological Image Guided Adaptive Radiotherapy Treatments (BIGART) as the means to improve the outcomes for patients with brain tumours. This will provide the blueprint for clinical radiotherapy trials to other solid tumours, bringing a paradigm shift in radiotherapy and leading to personalised treatments. 

 To promote these activities I work at the academic-clinical interface in close collaboration with UCLH's radiotherapy department and the City of London RADnet partners. 

Teaching Summary

I have teaching experience in both undergraduate and postgraduate physics, including project supervision for final year undergraduate, MSc and PhD students at the universities of Glasgow, Birmingham and Warwick. 

At UCL I teach the principles of Conformal Radiotherapy as part of the modules of "Treatment with  Ionising Radiation" (MPHY0038) and "Radiotherapy Physics" (MPHY0028). I also supervise MSc\MRes research projects (MPHY0034&35). 

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