Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Shane Minogue
Lipid and Membrane Biology group, UCL Institute for Liver and Digestive Health
Royal Free Campus
Tel: 020 7433 2785
Fax: 020 7433 2817
Dr Shane Minogue profile picture
  • Senior Lecturer
  • Education (Div of Med)
  • Div of Medicine
  • Faculty of Medical Sciences
Research Summary

We are interested in membrane trafficking controlled by the phosphoinositide lipids (PIs). PIs are constituents of endomembranes that are dynamically phosphorylated and dephosphorylated. These modifications can generate seven structurally and biochemically distinct lipid species that essentially contain a code specifying the recruitment of effector proteins. This ‘code’ defines regions within membranes that are particularly important in the sorting of membrane-bound cargoes into pathways leading to degradation and recycling.
As molecules that contain trafficking information the PIs are key determinants of membrane identity and, together with proteins such as the Rab GTPases, they control important membrane transport pathways that maintain the basic membrane organisation of the cell. Defects in PI metabolism can have dramatic effects on cell physiology, which accounts for our diverse interest in human diseases.


•    Molecular identification of the type II A and B PI 4-kinases.
•    Showed that PI4K2A regulates EGFR degradation.
•    Deletion of PI4K2A in mice leads to late-onset neurodegeneration (with P. Simons).
•    Cholesterol regulates PI4K2A mobility in TGN and endosomal membranes.
•    Demonstration that PI4K2A and PI4K2B synthesise PI4P in metabolically separate membrane domains.
•    PI4K2B regulates the formation of invasive structures.
•    Loss of PI4K2B function is a risk factor for human cancers.

Teaching Summary
  • MBBS Deputy Academic Lead Year 2.
  • MBBS Year 2 Cancer Biology (Module Lead).
  • MBBS Year 2 Genetics & Development (Module Lead).

Past teaching contributions: Cancer MSc (Lecturer), Molecular Medicine iBSc (Lecturer), Clinical Sciences iBSc (Lecturer).

Academic Background
1999   Doctor of Philosophy University College London
1994   Master of Science University College London
1992   Bachelor of Science King's College London
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by